TY - JOUR
T1 - Outcome in lacunar stroke
T2 - A cohort study
AU - Mantero, V.
AU - Scaccabarozzi, C.
AU - Botto, E.
AU - Giussani, G.
AU - Aliprandi, A.
AU - Lunghi, A.
AU - Ciusani, E.
AU - Brenna, G.
AU - Salmaggi, A.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Objectives: We evaluated a prospective cohort of 150 patients under observation in our centre for lacunar strokes. The purpose of this study was to evaluate the outcome at time of discharge and 6 months after lacunar stroke, as well as the correlation with cardiovascular risk factors and selected biochemical parameters already evaluated on admission. Focus was to identify possible prognostic factors, which might be targeted through appropriate intervention concentrating on reduction in the incidence and impact of early clinical deterioration. Methods: 150 patients with a lacunar stroke were included in the present study. A clinical 6-month follow-up was available for 98.7% of the patients. Infarcts were classified by size, shape and location. Results: The most important predictors of high NIHSS score at time of discharge resulted NIHSS on admission (P <.001), leukocytosis (P =.013), in-hospital infections (P =.016) and size of lacunae (P =.005). Similarly, the most important predictors of poor outcome 6 months later were NIHSS on admission (P =.01), leukocytosis (P =.014), elevated CRP (P =.019), in addition to pre-admission Rankin (P <.001). Conclusion: Although infections are not causatively related to lacunar strokes, their prompt recognition and early treatment, control of inflammatory markers and fever are most important in influencing functional outcome in lacunar stroke.
AB - Objectives: We evaluated a prospective cohort of 150 patients under observation in our centre for lacunar strokes. The purpose of this study was to evaluate the outcome at time of discharge and 6 months after lacunar stroke, as well as the correlation with cardiovascular risk factors and selected biochemical parameters already evaluated on admission. Focus was to identify possible prognostic factors, which might be targeted through appropriate intervention concentrating on reduction in the incidence and impact of early clinical deterioration. Methods: 150 patients with a lacunar stroke were included in the present study. A clinical 6-month follow-up was available for 98.7% of the patients. Infarcts were classified by size, shape and location. Results: The most important predictors of high NIHSS score at time of discharge resulted NIHSS on admission (P <.001), leukocytosis (P =.013), in-hospital infections (P =.016) and size of lacunae (P =.005). Similarly, the most important predictors of poor outcome 6 months later were NIHSS on admission (P =.01), leukocytosis (P =.014), elevated CRP (P =.019), in addition to pre-admission Rankin (P <.001). Conclusion: Although infections are not causatively related to lacunar strokes, their prompt recognition and early treatment, control of inflammatory markers and fever are most important in influencing functional outcome in lacunar stroke.
KW - C-reactive protein
KW - infections
KW - inflammatory markers
KW - lacunar stroke
KW - outcome
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U2 - 10.1111/ane.12961
DO - 10.1111/ane.12961
M3 - Article
C2 - 29770431
AN - SCOPUS:85047566045
VL - 138
SP - 320
EP - 326
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 4
ER -