Abstract
OBJECTIVE: We evaluated the sensitivity of various rehabilitation and lung function scales to detect differences between people with Charcot-Marie-Tooth (CMT) disease and healthy controls. We also studied whether these measurements are sensitive to disclose changes in patients with CMT disease after rehabilitative treatment. DESIGN: Eight patients with different types of CMT participated in the study. Data were gathered at baseline; at the end of the treadmill training, stretching, respiratory, and proprioceptive exercise (TreSPE) treatment period; and after a washout period of 6 mos. The following instruments were used for data collection: Medical Research Council scale for lower limb strength; Tinetti Balance Scale; Physical Performance Battery; ankle angle, oxygen consumption, and lung function tests; peak treadmill velocity and slope; time to walk 6 m; and CMT Neuropathy Score. The participants underwent TreSPE treatment twice every week for 8 wks. RESULTS: All rehabilitative measures were significantly worse in subjects with CMT disease than in healthy controls. Lung function was always normal except for the maximum expiratory pressure and maximum inspiratory pressure. No dropouts or worsening in any of the different outcome measures were observed after TreSPE. The ankle angle and the time to walk 6 m were the only measures that significantly improved after treatment. CONCLUSIONS: The rehabilitative outcome measures used in this protocol are useful in detecting clinical impairment in people with CMT disease. Lung function tests were confirmed to be minimally abnormal in patients with CMT disease. The TreSPE treatment, besides being safe and well tolerated, induced some training effects in CMT neuropathy, in the absence of lung function amelioration and effort tolerance. Follow-up showed that CMT patients should be treated at least twice every year because a regression of all outcome measures to the baseline state was found after a 6-mo washout period.
| Original language | English |
|---|---|
| Pages (from-to) | 628-637 |
| Number of pages | 10 |
| Journal | American Journal of Physical Medicine and Rehabilitation |
| Volume | 90 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2011 |
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Keywords
- Cardiopulmonary Effort Test
- Charcot-Marie-Tooth Disease
- Pulmonary Functions
- Treadmill Training
ASJC Scopus subject areas
- Rehabilitation
- Physical Therapy, Sports Therapy and Rehabilitation
- Medicine(all)
Cite this
Outcome measures and rehabilitation treatment in patients affected by charcot-marie-tooth neuropathy : A pilot study. / Maggi, Giovanni; Monti Bragadin, Margherita; Padua, Luca; Fiorina, Elisabetta; Bellone, Emilia; Grandis, Marina; Reni, Lizia; Bennicelli, Alessandra; Grosso, Manuela; Saporiti, Riccardo; Scorsone, Debora; Zuccarino, Riccardo; Crimi, Emanuele; Schenone, Angelo.
In: American Journal of Physical Medicine and Rehabilitation, Vol. 90, No. 8, 08.2011, p. 628-637.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcome measures and rehabilitation treatment in patients affected by charcot-marie-tooth neuropathy
T2 - A pilot study
AU - Maggi, Giovanni
AU - Monti Bragadin, Margherita
AU - Padua, Luca
AU - Fiorina, Elisabetta
AU - Bellone, Emilia
AU - Grandis, Marina
AU - Reni, Lizia
AU - Bennicelli, Alessandra
AU - Grosso, Manuela
AU - Saporiti, Riccardo
AU - Scorsone, Debora
AU - Zuccarino, Riccardo
AU - Crimi, Emanuele
AU - Schenone, Angelo
PY - 2011/8
Y1 - 2011/8
N2 - OBJECTIVE: We evaluated the sensitivity of various rehabilitation and lung function scales to detect differences between people with Charcot-Marie-Tooth (CMT) disease and healthy controls. We also studied whether these measurements are sensitive to disclose changes in patients with CMT disease after rehabilitative treatment. DESIGN: Eight patients with different types of CMT participated in the study. Data were gathered at baseline; at the end of the treadmill training, stretching, respiratory, and proprioceptive exercise (TreSPE) treatment period; and after a washout period of 6 mos. The following instruments were used for data collection: Medical Research Council scale for lower limb strength; Tinetti Balance Scale; Physical Performance Battery; ankle angle, oxygen consumption, and lung function tests; peak treadmill velocity and slope; time to walk 6 m; and CMT Neuropathy Score. The participants underwent TreSPE treatment twice every week for 8 wks. RESULTS: All rehabilitative measures were significantly worse in subjects with CMT disease than in healthy controls. Lung function was always normal except for the maximum expiratory pressure and maximum inspiratory pressure. No dropouts or worsening in any of the different outcome measures were observed after TreSPE. The ankle angle and the time to walk 6 m were the only measures that significantly improved after treatment. CONCLUSIONS: The rehabilitative outcome measures used in this protocol are useful in detecting clinical impairment in people with CMT disease. Lung function tests were confirmed to be minimally abnormal in patients with CMT disease. The TreSPE treatment, besides being safe and well tolerated, induced some training effects in CMT neuropathy, in the absence of lung function amelioration and effort tolerance. Follow-up showed that CMT patients should be treated at least twice every year because a regression of all outcome measures to the baseline state was found after a 6-mo washout period.
AB - OBJECTIVE: We evaluated the sensitivity of various rehabilitation and lung function scales to detect differences between people with Charcot-Marie-Tooth (CMT) disease and healthy controls. We also studied whether these measurements are sensitive to disclose changes in patients with CMT disease after rehabilitative treatment. DESIGN: Eight patients with different types of CMT participated in the study. Data were gathered at baseline; at the end of the treadmill training, stretching, respiratory, and proprioceptive exercise (TreSPE) treatment period; and after a washout period of 6 mos. The following instruments were used for data collection: Medical Research Council scale for lower limb strength; Tinetti Balance Scale; Physical Performance Battery; ankle angle, oxygen consumption, and lung function tests; peak treadmill velocity and slope; time to walk 6 m; and CMT Neuropathy Score. The participants underwent TreSPE treatment twice every week for 8 wks. RESULTS: All rehabilitative measures were significantly worse in subjects with CMT disease than in healthy controls. Lung function was always normal except for the maximum expiratory pressure and maximum inspiratory pressure. No dropouts or worsening in any of the different outcome measures were observed after TreSPE. The ankle angle and the time to walk 6 m were the only measures that significantly improved after treatment. CONCLUSIONS: The rehabilitative outcome measures used in this protocol are useful in detecting clinical impairment in people with CMT disease. Lung function tests were confirmed to be minimally abnormal in patients with CMT disease. The TreSPE treatment, besides being safe and well tolerated, induced some training effects in CMT neuropathy, in the absence of lung function amelioration and effort tolerance. Follow-up showed that CMT patients should be treated at least twice every year because a regression of all outcome measures to the baseline state was found after a 6-mo washout period.
KW - Cardiopulmonary Effort Test
KW - Charcot-Marie-Tooth Disease
KW - Pulmonary Functions
KW - Treadmill Training
UR - http://www.scopus.com/inward/record.url?scp=79960680204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960680204&partnerID=8YFLogxK
U2 - 10.1097/PHM.0b013e31821f6e32
DO - 10.1097/PHM.0b013e31821f6e32
M3 - Article
C2 - 21681064
AN - SCOPUS:79960680204
VL - 90
SP - 628
EP - 637
JO - American Journal of Physical Medicine and Rehabilitation
JF - American Journal of Physical Medicine and Rehabilitation
SN - 0894-9115
IS - 8
ER -