Outcome of 518 salvage oocyte-cryopreservation cycles performed as a routine procedure in an in vitro fertilization program

Giovanni B. La Sala, Alessia Nicoli, Maria T. Villani, Michela Pescarini, Andrea Gallinelli, Isaac Blickstein

Research output: Contribution to journalArticle

Abstract

Objective: To document outcomes of oocyte cryopreservation performed as a routine procedure in an IVF program. Design: Describing the rate of oocyte survival, embryo transfer (ET), implantation, and live births of IVF-intracytoplasmic sperm injection performed on thawed oocytes. Setting: Reproductive medicine center in Italy. Patient(s): Women (n = 696) who failed to conceive after IVF-intracytoplasmic sperm injection with fresh oocytes. Intervention(s): Surplus oocytes obtained during a failed cycle with fresh oocytes were frozen and then were thawed, micromanipulated, and transferred in a later cycle. Main Outcome Measure(s): Rates of oocyte survival, ETs, implantation, and live births were calculated in the entire cohort and in patients aged ≤38 and >38 years. Result(s): There were 29 pregnancies, for a total implantation rate of 6.3% (95% CI: 4.3, 9.0) per 456 ET cycles. The clinical-pregnancy rate was 19 (4.2%; 95% CI: 2.6, 6.4) of 456 ET cycles, with a take-home-baby rate of 7 (1.5%; 95% CI: 0.7, 3.0) of 456 ET cycles. Conclusion(s): Cryopreservation performed as a routine procedure for so-called salvaging of surplus oocytes is associated with poor implantation rates and with a probability of 1 live birth in 65 ET cycles.

Original languageEnglish
Pages (from-to)1423-1427
Number of pages5
JournalFertility and Sterility
Volume86
Issue number5
DOIs
Publication statusPublished - Nov 2006

Keywords

  • assisted reproduction
  • ICSI
  • IVF
  • oocyte cryopreservation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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