Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation

Ayad Ahmed Hussein, Constantijn M. Halkes, Gérard Socié, André Tichelli, Peter A. von dem Borne, Michel N P M Schaap, Robin Foa, Arnold Ganser, Carlo Dufour, Andrea Bacigalupo, Anna Locasciulli, Mahmoud Aljurf, Christina Peters, Marie Robin, Anja A. van Biezen, Liisa Volin, Theo De Witte, Judith Marsh, Jakob R. Passweg, Nicolas Kröger

Research output: Contribution to journalArticle

Abstract

One hundred and forty patients who had undergone hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) transformation after treatment of severe aplastic anemia (SAA) were identified in the European Group for Blood and Marrow Transplantation (EBMT) database. The median age at HSCT was 29years (range, 1 to 66years). The transplant donor was related in 49% cases and unrelated in 51% cases. The 5-year probability of relapse was 17%, and that of nonrelapse mortality was 41%. The 5-year overall survival was 45%±9%, better for patients untreated and patients in remission compared with patients with refractory disease. Our data indicate that allogeneic HSCT leads to prolonged survival in close to one-half of the patients transforming to MDS or AML from SAA.

Original languageEnglish
Pages (from-to)1448-1450
Number of pages3
JournalBiology of Blood and Marrow Transplantation
Volume20
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Acute myelogenous leukemia
  • Hematopoietic stem cell transplantation
  • Myelodysplastic syndrome
  • Severe aplastic anemia

ASJC Scopus subject areas

  • Transplantation
  • Hematology
  • Medicine(all)

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    Hussein, A. A., Halkes, C. M., Socié, G., Tichelli, A., von dem Borne, P. A., Schaap, M. N. P. M., Foa, R., Ganser, A., Dufour, C., Bacigalupo, A., Locasciulli, A., Aljurf, M., Peters, C., Robin, M., van Biezen, A. A., Volin, L., De Witte, T., Marsh, J., Passweg, J. R., & Kröger, N. (2014). Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation. Biology of Blood and Marrow Transplantation, 20(9), 1448-1450. https://doi.org/10.1016/j.bbmt.2014.05.028