Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation

Ayad Ahmed Hussein; Constantijn M. Halkes; Gérard Socié; André Tichelli; Peter A. von dem Borne; Michel N P M Schaap; Robin Foa; Arnold Ganser; Carlo Dufour; Andrea Bacigalupo; Anna Locasciulli; Mahmoud Aljurf; Christina Peters; Marie Robin; Anja A. van Biezen; Liisa Volin; Theo De Witte; Judith Marsh; Jakob R. Passweg; Nicolas Kröger

doi:10.1016/j.bbmt.2014.05.028

Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation

Ayad Ahmed Hussein, Constantijn M. Halkes, Gérard Socié, André Tichelli, Peter A. von dem Borne, Michel N P M Schaap, Robin Foa, Arnold Ganser, Carlo Dufour, Andrea Bacigalupo, Anna Locasciulli, Mahmoud Aljurf, Christina Peters, Marie Robin, Anja A. van Biezen, Liisa Volin, Theo De Witte, Judith Marsh, Jakob R. Passweg, Nicolas Kröger

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article

Abstract

One hundred and forty patients who had undergone hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) transformation after treatment of severe aplastic anemia (SAA) were identified in the European Group for Blood and Marrow Transplantation (EBMT) database. The median age at HSCT was 29years (range, 1 to 66years). The transplant donor was related in 49% cases and unrelated in 51% cases. The 5-year probability of relapse was 17%, and that of nonrelapse mortality was 41%. The 5-year overall survival was 45%±9%, better for patients untreated and patients in remission compared with patients with refractory disease. Our data indicate that allogeneic HSCT leads to prolonged survival in close to one-half of the patients transforming to MDS or AML from SAA.

Original language	English
Pages (from-to)	1448-1450
Number of pages	3
Journal	Biology of Blood and Marrow Transplantation
Volume	20
Issue number	9
DOIs	https://doi.org/10.1016/j.bbmt.2014.05.028
Publication status	Published - 2014

Keywords

Acute myelogenous leukemia
Hematopoietic stem cell transplantation
Myelodysplastic syndrome
Severe aplastic anemia

ASJC Scopus subject areas

Transplantation
Hematology
Medicine(all)

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Hussein, A. A., Halkes, C. M., Socié, G., Tichelli, A., von dem Borne, P. A., Schaap, M. N. P. M., Foa, R., Ganser, A., Dufour, C., Bacigalupo, A., Locasciulli, A., Aljurf, M., Peters, C., Robin, M., van Biezen, A. A., Volin, L., De Witte, T., Marsh, J., Passweg, J. R., & Kröger, N. (2014). Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation. Biology of Blood and Marrow Transplantation, 20(9), 1448-1450. https://doi.org/10.1016/j.bbmt.2014.05.028

Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia : A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation. / Hussein, Ayad Ahmed; Halkes, Constantijn M.; Socié, Gérard; Tichelli, André; von dem Borne, Peter A.; Schaap, Michel N P M; Foa, Robin; Ganser, Arnold; Dufour, Carlo; Bacigalupo, Andrea; Locasciulli, Anna; Aljurf, Mahmoud; Peters, Christina; Robin, Marie; van Biezen, Anja A.; Volin, Liisa; De Witte, Theo; Marsh, Judith; Passweg, Jakob R.; Kröger, Nicolas.

In: Biology of Blood and Marrow Transplantation, Vol. 20, No. 9, 2014, p. 1448-1450.

Research output: Contribution to journal › Article

Hussein, AA, Halkes, CM, Socié, G, Tichelli, A, von dem Borne, PA, Schaap, MNPM, Foa, R, Ganser, A, Dufour, C, Bacigalupo, A, Locasciulli, A, Aljurf, M, Peters, C, Robin, M, van Biezen, AA, Volin, L, De Witte, T, Marsh, J, Passweg, JR & Kröger, N 2014, 'Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation', Biology of Blood and Marrow Transplantation, vol. 20, no. 9, pp. 1448-1450. https://doi.org/10.1016/j.bbmt.2014.05.028

Hussein AA, Halkes CM, Socié G, Tichelli A, von dem Borne PA, Schaap MNPM et al. Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation. Biology of Blood and Marrow Transplantation. 2014;20(9):1448-1450. https://doi.org/10.1016/j.bbmt.2014.05.028

Hussein, Ayad Ahmed ; Halkes, Constantijn M. ; Socié, Gérard ; Tichelli, André ; von dem Borne, Peter A. ; Schaap, Michel N P M ; Foa, Robin ; Ganser, Arnold ; Dufour, Carlo ; Bacigalupo, Andrea ; Locasciulli, Anna ; Aljurf, Mahmoud ; Peters, Christina ; Robin, Marie ; van Biezen, Anja A. ; Volin, Liisa ; De Witte, Theo ; Marsh, Judith ; Passweg, Jakob R. ; Kröger, Nicolas. / Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia : A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation. In: Biology of Blood and Marrow Transplantation. 2014 ; Vol. 20, No. 9. pp. 1448-1450.

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title = "Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: A report from the mds subcommittee of the chronic malignancies working party and the severe aplastic anemia working party of the european group for blood and marrow transplantation",

abstract = "One hundred and forty patients who had undergone hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) transformation after treatment of severe aplastic anemia (SAA) were identified in the European Group for Blood and Marrow Transplantation (EBMT) database. The median age at HSCT was 29years (range, 1 to 66years). The transplant donor was related in 49% cases and unrelated in 51% cases. The 5-year probability of relapse was 17%, and that of nonrelapse mortality was 41%. The 5-year overall survival was 45%±9%, better for patients untreated and patients in remission compared with patients with refractory disease. Our data indicate that allogeneic HSCT leads to prolonged survival in close to one-half of the patients transforming to MDS or AML from SAA.",

keywords = "Acute myelogenous leukemia, Hematopoietic stem cell transplantation, Myelodysplastic syndrome, Severe aplastic anemia",

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AU - Hussein, Ayad Ahmed

AU - Halkes, Constantijn M.

AU - Socié, Gérard

AU - Tichelli, André

AU - von dem Borne, Peter A.

AU - Schaap, Michel N P M

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AU - Ganser, Arnold

AU - Dufour, Carlo

AU - Bacigalupo, Andrea

AU - Locasciulli, Anna

AU - Aljurf, Mahmoud

AU - Peters, Christina

AU - Robin, Marie

AU - van Biezen, Anja A.

AU - Volin, Liisa

AU - De Witte, Theo

AU - Marsh, Judith

AU - Passweg, Jakob R.

AU - Kröger, Nicolas

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