Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies

Alberto Larghi, Massimo Zuin, Andrea Crosignani, Maria Lisa Ribero, Cristina Pipia, Pier Maria Battezzati, Giorgio Binelli, Francesco Donato, Alessandro Remo Zanetti, Mauro Podda, Alessandro Tagger

Research output: Contribution to journalArticlepeer-review


We identified 15 patients with acute hepatitis C (AHC) among 29 healthy volunteers participating in 2 consecutive pharmacokinetics studies. Molecular techniques were used to determine the relatedness of viral strains, whereas clinical and virologic follow-up was started to establish the course and outcome of the acute infection. After presentation, serum liver enzymes and HCV RNA were monitored weekly for 4 months, then monthly for at least 12 months. Liver biopsy was performed 6 to 12 months after AHC diagnosis. Phylogenetic analysis of coding regions for the envelope glycoproteins E1 and E2 was performed. At presentation, all 15 patients tested HCV RNA-positive and had HCV genotype 2c. Phylogenetic analysis indicated a common source of infection. Fourteen patients agreed to be followed prospectively. Infection resolved spontaneously in 8 patients, HCV RNA becoming undetectable by 4 to 5 months after the presumed time of infection in 5 of them and by 8, 13, and 24 months in the remaining 3. Six patients developed chronic infection. Liver biopsies performed in 9 subjects who were HCV RNA-positive 6 months after AHC diagnosis revealed that the prevalent histologic finding was lobular inflammation. In conclusion, our homogeneous cohort showed a wide spectrum of clinical, virologic and histologic features, and, more importantly, short-term outcome differed noticeably despite the common source of infection.

Original languageEnglish
Pages (from-to)993-1000
Number of pages8
Issue number4 I
Publication statusPublished - Oct 1 2002

ASJC Scopus subject areas

  • Hepatology


Dive into the research topics of 'Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies'. Together they form a unique fingerprint.

Cite this