Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Theodor Uden, Alice Bertaina, Jonas Abrahamsson, Marc Ansari, Adriana Balduzzi, Jean Pierre Bourquin, Corinne Gerhardt, Marc Bierings, Henrik Hasle, Arjan Lankester, Kirsten Mischke, Andrew S. Moore, Ian Nivison-Smith, Anna Pieczonka, Christina Peters, Petr Sedlacek, Dirk Reinhardt, Jerry Stein, Birgitta Versluys, Jacek WachowiakLeen Willems, Martin Zimmermann, Franco Locatelli, Martin G. Sauer

Research output: Contribution to journalArticlepeer-review

Abstract

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

Original languageEnglish
Pages (from-to)745-750
Number of pages6
JournalBritish Journal of Haematology
Volume189
Issue number4
DOIs
Publication statusPublished - May 1 2020

Keywords

  • acute myeloid leukemia
  • allogeneic hematopoietic stem cell transplantation
  • children
  • relapse
  • second hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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