Outcome of endotherapy for pancreas divisum in patients with acute recurrent pancreatitis

Alberto Mariani, Milena Di Leo, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Antonella Giussani, Raffaella Alessia Zuppardo, Giulia Martina Cavestro, Pier Alberto Testoni

Research output: Contribution to journalArticlepeer-review


AIM: To assess the rate of relapses of acute pancreatitis (AP), recurrent AP (RAP) and the evolution of endosonographic signs of chronic pancreatitis (CP) in patients with pancreas divisum (PDiv) and RAP.

METHODS: Over a five-year period, patients with PDiv and RAP prospectively enrolled were divided into two groups: (1) those with relapses of AP in the year before enrollment were assigned to have endoscopic therapy (recent RAP group); and (2) those free of recurrences were conservatively managed, unless they relapsed during follow-up (previous RAP group). All patients in both groups entered a follow-up protocol that included clinical and biochemical evaluation, pancreatic endoscopic ultrasonography (EUS) every year and after every recurrence of A P, at the same time as endoscopic retrograde cholangiopancreatography (ERCP).

RESULTS: Twenty-two were treated by ERCP and 14 were conservatively managed during a mean follow-up of 4.5 ± 1.2 years. In the recent RAP group in whom dorsal duct drainage was achieved, AP still recurred in 11 (57.9%) after the first ERCP, in 6 after the second ERCP (31.6%) and in 5 after the third ERCP (26.3%). Overall, endotherapy was successful 73.7%. There were no cases of recurrences in the previous RAP group. EUS signs of CP developed in 57.9% of treated and 64.3% of untreated patients. EUS signs of CP occurred in 42.8% of patients whose ERCPs were successful and in all those in whom it was unsuccessful (P = 0.04). There were no significant differences in the rate of AP recurrences after endotherapy and in the prevalence of EUS signs suggesting CP when comparing patients with dilated and non-dilated dorsal pancreatic ducts within each group.

CONCLUSION: Patients with PDiv and recent episodes of AP can benefit from endoscopic therapy. Effective endotherapy may reduce the risk of developing EUS signs of CP at a rate similar to that seen in patients of previous RAP group, managed conservatively. However, in a subset of patients, endotherapy, although successful, did not prevent the evolution of endosonographic signs of CP.

Original languageEnglish
Pages (from-to)17468-17475
Number of pages8
JournalWorld Journal of Gastroenterology
Issue number46
Publication statusPublished - Dec 14 2014


  • Endoscopic retrograde cholangiopancreatography
  • Endoscopic ultrasonography
  • Magnetic resonance cholangiopancreatography with secretin stimulation
  • Minor papilla endotherapy
  • Pancreatic stenting

ASJC Scopus subject areas

  • Gastroenterology


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