Outcome of hepatic artery reconstruction in liver transplantation with an iliac arterial interposition graft

Massimo Del Gaudio, Gian Luca Grazi, Giorgio Ercolani, Matteo Ravaioli, Giovanni Varotti, Matteo Cescon, Gaetano Vetrone, Giovanni Ramacciato, Antonio Daniele Pinna

Research output: Contribution to journalArticle

Abstract

Background: In case of anomal hepatic arterial inflow, it can be necessary to perform revascularization of the liver allograft by iliac arterial interposition graft. Methods: We analyzed retrospectively 613 liver transplants in a 16-yr period. The hepatic artery (HA) graft group (n = 101) consisted of patients with arterial inflow based on recipient infrarenal aorta using donor iliac artery graft tunneled through the transverse mesocolon. The control group (n = 512) consisted of patients who underwent liver transplantation with routine HA reconstruction. Results: Both groups are homogeneous and comparable. In case of retransplantation, arterial conduit with iliac graft was adopted more frequently instead of conventional arterial anastomosis (24.8% vs. 9%, p <0.0001). The 1-, 3- and 5-yr overall survival was 85.41, 79.42, 76.57% in the control group and 76.21, 73.43, 73.43% in the HA graft group, respectively (p = ns). The 1-, 3- and 5-yr graft survival was better in the control group (81.51, 73.66, 69.22% vs. 71.17, 62.50, 53.42%) (p = 0.01). In case of retransplantation, the 1-, 3- and 5-yr overall (57.81, 53.95, 41.96% vs. 60, 51.95, 49.85%) and graft survival (57.52, 53.68, 41.75% vs. 56, 50.4, 40.3%) was similar in control and HA graft group, respectively (p = ns). Hepatic artery thrombosis (HAT) rate is 21.8% vs. 8.6% (p <0.0001) in HA graft group and control group, respectively. The only factor independently predictive of early HAT resulted arterial conduit (p = 0.001, OR = 3.13, 95% CI: 1.57-6.21). Retransplant procedure, donor age and arterial iliac conduit were found to be a significant risk factors for late HAT, at univariate analysis. At multivariate analysis, donor age > 50 yr old resulted the only factor independently associated with late HAT (p <0.0001, OR = 1.05, 95% CI: 1.02-1.07). Conclusion: Iliac arterial interpositional graft is an alternative solution for arterial revascularization of liver allograft in case of retransplantation when the use of HA is not possible. In case of primary transplantation, is better not to perform arterial conduit if it is possible, for poor graft survival and high incidence of early HAT, especially in case of liver donor aged over 50 yr.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalClinical Transplantation
Volume19
Issue number3
DOIs
Publication statusPublished - Jun 2005

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Hepatic Artery
Liver Transplantation
Transplants
Liver
Allografts
Mesocolon
Tissue Donors
Iliac Artery
Graft Survival
Aorta
Transplantation
Control Groups
Incidence

Keywords

  • Hepatic artery
  • Iliac artery graft
  • Retransplantation
  • Thrombosis

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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Outcome of hepatic artery reconstruction in liver transplantation with an iliac arterial interposition graft. / Del Gaudio, Massimo; Grazi, Gian Luca; Ercolani, Giorgio; Ravaioli, Matteo; Varotti, Giovanni; Cescon, Matteo; Vetrone, Gaetano; Ramacciato, Giovanni; Pinna, Antonio Daniele.

In: Clinical Transplantation, Vol. 19, No. 3, 06.2005, p. 399-405.

Research output: Contribution to journalArticle

Del Gaudio, M, Grazi, GL, Ercolani, G, Ravaioli, M, Varotti, G, Cescon, M, Vetrone, G, Ramacciato, G & Pinna, AD 2005, 'Outcome of hepatic artery reconstruction in liver transplantation with an iliac arterial interposition graft', Clinical Transplantation, vol. 19, no. 3, pp. 399-405. https://doi.org/10.1111/j.1399-0012.2005.00363.x
Del Gaudio, Massimo ; Grazi, Gian Luca ; Ercolani, Giorgio ; Ravaioli, Matteo ; Varotti, Giovanni ; Cescon, Matteo ; Vetrone, Gaetano ; Ramacciato, Giovanni ; Pinna, Antonio Daniele. / Outcome of hepatic artery reconstruction in liver transplantation with an iliac arterial interposition graft. In: Clinical Transplantation. 2005 ; Vol. 19, No. 3. pp. 399-405.
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abstract = "Background: In case of anomal hepatic arterial inflow, it can be necessary to perform revascularization of the liver allograft by iliac arterial interposition graft. Methods: We analyzed retrospectively 613 liver transplants in a 16-yr period. The hepatic artery (HA) graft group (n = 101) consisted of patients with arterial inflow based on recipient infrarenal aorta using donor iliac artery graft tunneled through the transverse mesocolon. The control group (n = 512) consisted of patients who underwent liver transplantation with routine HA reconstruction. Results: Both groups are homogeneous and comparable. In case of retransplantation, arterial conduit with iliac graft was adopted more frequently instead of conventional arterial anastomosis (24.8{\%} vs. 9{\%}, p <0.0001). The 1-, 3- and 5-yr overall survival was 85.41, 79.42, 76.57{\%} in the control group and 76.21, 73.43, 73.43{\%} in the HA graft group, respectively (p = ns). The 1-, 3- and 5-yr graft survival was better in the control group (81.51, 73.66, 69.22{\%} vs. 71.17, 62.50, 53.42{\%}) (p = 0.01). In case of retransplantation, the 1-, 3- and 5-yr overall (57.81, 53.95, 41.96{\%} vs. 60, 51.95, 49.85{\%}) and graft survival (57.52, 53.68, 41.75{\%} vs. 56, 50.4, 40.3{\%}) was similar in control and HA graft group, respectively (p = ns). Hepatic artery thrombosis (HAT) rate is 21.8{\%} vs. 8.6{\%} (p <0.0001) in HA graft group and control group, respectively. The only factor independently predictive of early HAT resulted arterial conduit (p = 0.001, OR = 3.13, 95{\%} CI: 1.57-6.21). Retransplant procedure, donor age and arterial iliac conduit were found to be a significant risk factors for late HAT, at univariate analysis. At multivariate analysis, donor age > 50 yr old resulted the only factor independently associated with late HAT (p <0.0001, OR = 1.05, 95{\%} CI: 1.02-1.07). Conclusion: Iliac arterial interpositional graft is an alternative solution for arterial revascularization of liver allograft in case of retransplantation when the use of HA is not possible. In case of primary transplantation, is better not to perform arterial conduit if it is possible, for poor graft survival and high incidence of early HAT, especially in case of liver donor aged over 50 yr.",
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AU - Del Gaudio, Massimo

AU - Grazi, Gian Luca

AU - Ercolani, Giorgio

AU - Ravaioli, Matteo

AU - Varotti, Giovanni

AU - Cescon, Matteo

AU - Vetrone, Gaetano

AU - Ramacciato, Giovanni

AU - Pinna, Antonio Daniele

PY - 2005/6

Y1 - 2005/6

N2 - Background: In case of anomal hepatic arterial inflow, it can be necessary to perform revascularization of the liver allograft by iliac arterial interposition graft. Methods: We analyzed retrospectively 613 liver transplants in a 16-yr period. The hepatic artery (HA) graft group (n = 101) consisted of patients with arterial inflow based on recipient infrarenal aorta using donor iliac artery graft tunneled through the transverse mesocolon. The control group (n = 512) consisted of patients who underwent liver transplantation with routine HA reconstruction. Results: Both groups are homogeneous and comparable. In case of retransplantation, arterial conduit with iliac graft was adopted more frequently instead of conventional arterial anastomosis (24.8% vs. 9%, p <0.0001). The 1-, 3- and 5-yr overall survival was 85.41, 79.42, 76.57% in the control group and 76.21, 73.43, 73.43% in the HA graft group, respectively (p = ns). The 1-, 3- and 5-yr graft survival was better in the control group (81.51, 73.66, 69.22% vs. 71.17, 62.50, 53.42%) (p = 0.01). In case of retransplantation, the 1-, 3- and 5-yr overall (57.81, 53.95, 41.96% vs. 60, 51.95, 49.85%) and graft survival (57.52, 53.68, 41.75% vs. 56, 50.4, 40.3%) was similar in control and HA graft group, respectively (p = ns). Hepatic artery thrombosis (HAT) rate is 21.8% vs. 8.6% (p <0.0001) in HA graft group and control group, respectively. The only factor independently predictive of early HAT resulted arterial conduit (p = 0.001, OR = 3.13, 95% CI: 1.57-6.21). Retransplant procedure, donor age and arterial iliac conduit were found to be a significant risk factors for late HAT, at univariate analysis. At multivariate analysis, donor age > 50 yr old resulted the only factor independently associated with late HAT (p <0.0001, OR = 1.05, 95% CI: 1.02-1.07). Conclusion: Iliac arterial interpositional graft is an alternative solution for arterial revascularization of liver allograft in case of retransplantation when the use of HA is not possible. In case of primary transplantation, is better not to perform arterial conduit if it is possible, for poor graft survival and high incidence of early HAT, especially in case of liver donor aged over 50 yr.

AB - Background: In case of anomal hepatic arterial inflow, it can be necessary to perform revascularization of the liver allograft by iliac arterial interposition graft. Methods: We analyzed retrospectively 613 liver transplants in a 16-yr period. The hepatic artery (HA) graft group (n = 101) consisted of patients with arterial inflow based on recipient infrarenal aorta using donor iliac artery graft tunneled through the transverse mesocolon. The control group (n = 512) consisted of patients who underwent liver transplantation with routine HA reconstruction. Results: Both groups are homogeneous and comparable. In case of retransplantation, arterial conduit with iliac graft was adopted more frequently instead of conventional arterial anastomosis (24.8% vs. 9%, p <0.0001). The 1-, 3- and 5-yr overall survival was 85.41, 79.42, 76.57% in the control group and 76.21, 73.43, 73.43% in the HA graft group, respectively (p = ns). The 1-, 3- and 5-yr graft survival was better in the control group (81.51, 73.66, 69.22% vs. 71.17, 62.50, 53.42%) (p = 0.01). In case of retransplantation, the 1-, 3- and 5-yr overall (57.81, 53.95, 41.96% vs. 60, 51.95, 49.85%) and graft survival (57.52, 53.68, 41.75% vs. 56, 50.4, 40.3%) was similar in control and HA graft group, respectively (p = ns). Hepatic artery thrombosis (HAT) rate is 21.8% vs. 8.6% (p <0.0001) in HA graft group and control group, respectively. The only factor independently predictive of early HAT resulted arterial conduit (p = 0.001, OR = 3.13, 95% CI: 1.57-6.21). Retransplant procedure, donor age and arterial iliac conduit were found to be a significant risk factors for late HAT, at univariate analysis. At multivariate analysis, donor age > 50 yr old resulted the only factor independently associated with late HAT (p <0.0001, OR = 1.05, 95% CI: 1.02-1.07). Conclusion: Iliac arterial interpositional graft is an alternative solution for arterial revascularization of liver allograft in case of retransplantation when the use of HA is not possible. In case of primary transplantation, is better not to perform arterial conduit if it is possible, for poor graft survival and high incidence of early HAT, especially in case of liver donor aged over 50 yr.

KW - Hepatic artery

KW - Iliac artery graft

KW - Retransplantation

KW - Thrombosis

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