Outcome of Immediate Breast Reconstruction in Patients with Nonendocrine-Responsive Breast Cancer: A Monoinstitutional Case-Control Study

Gaetano Aurilio, Vincenzo Bagnardi, Franco Nolè, Giancarlo Pruneri, Rossella Graffeo, Jean Yves Petit, Daniela Cullurà, Stefano Martella, Marzia Locatelli, Marco Iera, Piercarlo Rey, Giuseppe Curigliano, Nicole Rotmensz, Elisabetta Munzone, Aron Goldhirsch

Research output: Contribution to journalArticlepeer-review

Abstract

Background The long-term prognostic relevance of immediate breast reconstruction (IBR) for patients with estrogen receptor (ER)-negative breast cancer (BC) has not been fully elucidated. Patients and Methods The study population included 444 patients with ER-negative BC who underwent total mastectomy with complete axillary dissection between 1995 and 2006, 339 patients with and 105 patients without IBR. The median follow-up was 8.6 years. Results Patients treated with IBR were younger (P 4 lymph nodes involvement: 29.5% vs. 45.7%; P =.0026), smaller tumors (pT1/2: 15% vs. 26.7%; P =.0007), and lower extent of peritumoral vascular invasion (15.9% vs. 21%; P =.032). The 5-year cumulative incidence of locoregional recurrence was 7.1% in the IBR group and 11.7% in the no IBR group (hazard ratio [HR], 0.81; P =.63). The 5-year cumulative incidence of distant metastases were similar in the 2 groups (P =.79). The 5-year overall and disease-free survival proportions were 79.9% versus 69.5% (HR, 1.11; P =.67) and 66.6% versus 54.1% (HR, 1.04; P =.83) in the IBR group and no IBR group, respectively. Conclusion IBR intervention does not significantly affect prognosis of ER-negative BC patients.

Original languageEnglish
Pages (from-to)e237-e241
JournalClinical Breast Cancer
Volume15
Issue number5
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • Case-Control Study
  • Immediate Breast Reconstruction
  • Invasive breast cancer
  • Nonendocrine responsive patients
  • Outcome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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