Outcome of Immediate Breast Reconstruction in Patients with Nonendocrine-Responsive Breast Cancer: A Monoinstitutional Case-Control Study

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Abstract

Background The long-term prognostic relevance of immediate breast reconstruction (IBR) for patients with estrogen receptor (ER)-negative breast cancer (BC) has not been fully elucidated. Patients and Methods The study population included 444 patients with ER-negative BC who underwent total mastectomy with complete axillary dissection between 1995 and 2006, 339 patients with and 105 patients without IBR. The median follow-up was 8.6 years. Results Patients treated with IBR were younger (P 4 lymph nodes involvement: 29.5% vs. 45.7%; P =.0026), smaller tumors (pT1/2: 15% vs. 26.7%; P =.0007), and lower extent of peritumoral vascular invasion (15.9% vs. 21%; P =.032). The 5-year cumulative incidence of locoregional recurrence was 7.1% in the IBR group and 11.7% in the no IBR group (hazard ratio [HR], 0.81; P =.63). The 5-year cumulative incidence of distant metastases were similar in the 2 groups (P =.79). The 5-year overall and disease-free survival proportions were 79.9% versus 69.5% (HR, 1.11; P =.67) and 66.6% versus 54.1% (HR, 1.04; P =.83) in the IBR group and no IBR group, respectively. Conclusion IBR intervention does not significantly affect prognosis of ER-negative BC patients.

Original languageEnglish
Pages (from-to)e237-e241
JournalClinical Breast Cancer
Volume15
Issue number5
DOIs
Publication statusPublished - Oct 1 2015

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Mammaplasty
Case-Control Studies
Breast Neoplasms
Estrogen Receptors
Simple Mastectomy
Incidence
Disease-Free Survival
Blood Vessels
Dissection
Lymph Nodes
Neoplasm Metastasis
Recurrence

Keywords

  • Case-Control Study
  • Immediate Breast Reconstruction
  • Invasive breast cancer
  • Nonendocrine responsive patients
  • Outcome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

@article{0942106c08e543558813fe4830037742,
title = "Outcome of Immediate Breast Reconstruction in Patients with Nonendocrine-Responsive Breast Cancer: A Monoinstitutional Case-Control Study",
abstract = "Background The long-term prognostic relevance of immediate breast reconstruction (IBR) for patients with estrogen receptor (ER)-negative breast cancer (BC) has not been fully elucidated. Patients and Methods The study population included 444 patients with ER-negative BC who underwent total mastectomy with complete axillary dissection between 1995 and 2006, 339 patients with and 105 patients without IBR. The median follow-up was 8.6 years. Results Patients treated with IBR were younger (P 4 lymph nodes involvement: 29.5{\%} vs. 45.7{\%}; P =.0026), smaller tumors (pT1/2: 15{\%} vs. 26.7{\%}; P =.0007), and lower extent of peritumoral vascular invasion (15.9{\%} vs. 21{\%}; P =.032). The 5-year cumulative incidence of locoregional recurrence was 7.1{\%} in the IBR group and 11.7{\%} in the no IBR group (hazard ratio [HR], 0.81; P =.63). The 5-year cumulative incidence of distant metastases were similar in the 2 groups (P =.79). The 5-year overall and disease-free survival proportions were 79.9{\%} versus 69.5{\%} (HR, 1.11; P =.67) and 66.6{\%} versus 54.1{\%} (HR, 1.04; P =.83) in the IBR group and no IBR group, respectively. Conclusion IBR intervention does not significantly affect prognosis of ER-negative BC patients.",
keywords = "Case-Control Study, Immediate Breast Reconstruction, Invasive breast cancer, Nonendocrine responsive patients, Outcome",
author = "Gaetano Aurilio and Vincenzo Bagnardi and Franco Nol{\`e} and Giancarlo Pruneri and Rossella Graffeo and Petit, {Jean Yves} and Daniela Cullur{\`a} and Stefano Martella and Marzia Locatelli and Marco Iera and Piercarlo Rey and Giuseppe Curigliano and Nicole Rotmensz and Elisabetta Munzone and Aron Goldhirsch",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.clbc.2015.03.009",
language = "English",
volume = "15",
pages = "e237--e241",
journal = "Clinical Breast Cancer",
issn = "1526-8209",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Outcome of Immediate Breast Reconstruction in Patients with Nonendocrine-Responsive Breast Cancer

T2 - A Monoinstitutional Case-Control Study

AU - Aurilio, Gaetano

AU - Bagnardi, Vincenzo

AU - Nolè, Franco

AU - Pruneri, Giancarlo

AU - Graffeo, Rossella

AU - Petit, Jean Yves

AU - Cullurà, Daniela

AU - Martella, Stefano

AU - Locatelli, Marzia

AU - Iera, Marco

AU - Rey, Piercarlo

AU - Curigliano, Giuseppe

AU - Rotmensz, Nicole

AU - Munzone, Elisabetta

AU - Goldhirsch, Aron

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background The long-term prognostic relevance of immediate breast reconstruction (IBR) for patients with estrogen receptor (ER)-negative breast cancer (BC) has not been fully elucidated. Patients and Methods The study population included 444 patients with ER-negative BC who underwent total mastectomy with complete axillary dissection between 1995 and 2006, 339 patients with and 105 patients without IBR. The median follow-up was 8.6 years. Results Patients treated with IBR were younger (P 4 lymph nodes involvement: 29.5% vs. 45.7%; P =.0026), smaller tumors (pT1/2: 15% vs. 26.7%; P =.0007), and lower extent of peritumoral vascular invasion (15.9% vs. 21%; P =.032). The 5-year cumulative incidence of locoregional recurrence was 7.1% in the IBR group and 11.7% in the no IBR group (hazard ratio [HR], 0.81; P =.63). The 5-year cumulative incidence of distant metastases were similar in the 2 groups (P =.79). The 5-year overall and disease-free survival proportions were 79.9% versus 69.5% (HR, 1.11; P =.67) and 66.6% versus 54.1% (HR, 1.04; P =.83) in the IBR group and no IBR group, respectively. Conclusion IBR intervention does not significantly affect prognosis of ER-negative BC patients.

AB - Background The long-term prognostic relevance of immediate breast reconstruction (IBR) for patients with estrogen receptor (ER)-negative breast cancer (BC) has not been fully elucidated. Patients and Methods The study population included 444 patients with ER-negative BC who underwent total mastectomy with complete axillary dissection between 1995 and 2006, 339 patients with and 105 patients without IBR. The median follow-up was 8.6 years. Results Patients treated with IBR were younger (P 4 lymph nodes involvement: 29.5% vs. 45.7%; P =.0026), smaller tumors (pT1/2: 15% vs. 26.7%; P =.0007), and lower extent of peritumoral vascular invasion (15.9% vs. 21%; P =.032). The 5-year cumulative incidence of locoregional recurrence was 7.1% in the IBR group and 11.7% in the no IBR group (hazard ratio [HR], 0.81; P =.63). The 5-year cumulative incidence of distant metastases were similar in the 2 groups (P =.79). The 5-year overall and disease-free survival proportions were 79.9% versus 69.5% (HR, 1.11; P =.67) and 66.6% versus 54.1% (HR, 1.04; P =.83) in the IBR group and no IBR group, respectively. Conclusion IBR intervention does not significantly affect prognosis of ER-negative BC patients.

KW - Case-Control Study

KW - Immediate Breast Reconstruction

KW - Invasive breast cancer

KW - Nonendocrine responsive patients

KW - Outcome

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U2 - 10.1016/j.clbc.2015.03.009

DO - 10.1016/j.clbc.2015.03.009

M3 - Article

C2 - 25908443

AN - SCOPUS:84941315153

VL - 15

SP - e237-e241

JO - Clinical Breast Cancer

JF - Clinical Breast Cancer

SN - 1526-8209

IS - 5

ER -