TY - JOUR
T1 - Outcome of male breast cancer
T2 - A matched single-institution series
AU - Iorfida, Monica
AU - Bagnardi, Vincenzo
AU - Rotmensz, Nicole
AU - Munzone, Elisabetta
AU - Bonanni, Bernardo
AU - Viale, Giuseppe
AU - Pruneri, Giancarlo
AU - Mazza, Manuelita
AU - Cardillo, Anna
AU - Veronesi, Paolo
AU - Luini, Alberto
AU - Galimberti, Viviana
AU - Goldhirsch, Aron
AU - Colleoni, Marco
PY - 2014
Y1 - 2014
N2 - Given that male breast cancer is a rare entity we analyzed a total of 99 consecutive cases of male breast cancer matched with 198 women. The aim was to better understand prognosis of the male compared to the female breast cancer. We found that men with breast cancer had a poorer DFS and OS when compared with women. Background: Breast cancer occurs rarely in men, accounting for approximately 1% of all breast carcinomas. Data on prognosis principally derive from retrospective studies and from extrapolation of female breast cancer series. Patients and Methods: A total of 99 men with invasive breast cancer were matched with 198 women with breast cancer who had surgery at the same institution from 1999 to 2010. Matching variables were year of surgery, age, primary tumor size, nodal involvement, hormone receptor status, status of HER2 (human epidermal growth factor receptor 2 [ERBB2]), Ki-67, and grade. Median follow-up was 8.6 years. Results: Disease-free survival (DFS) was significantly poorer in the men (10-year DFS, 51.7% vs. 66.5%; hazard ratio [HR], 1.79; 95% CI, 1.19-2.68; P = .004). Similar results were observed for overall survival (OS) (10-year OS, 70.7% vs. 84.2%; HR, 1.79; 95% CI, 1.01-3.15; P = .043). The cumulative incidence of death for causes not related to the primary breast cancer was significantly higher for men than for women (HR, 2.87; 95% CI, 1.58-5.22; P = .001), whereas the breast cancerespecific survival (BCSS) was similar between the 2 groups (10-year BCSS, 81.5% vs. 88%; HR, 1.27; 95% CI, 0.62-2.59; P = .517). Conclusion: This comparative series found that men with breast cancer had a poorer DFS and OS when compared with women. The men also had a higher risk of contralateral tumors and second primaries. Appropriate counseling, surveillance, and prevention are recommended to improve survival for these individuals.
AB - Given that male breast cancer is a rare entity we analyzed a total of 99 consecutive cases of male breast cancer matched with 198 women. The aim was to better understand prognosis of the male compared to the female breast cancer. We found that men with breast cancer had a poorer DFS and OS when compared with women. Background: Breast cancer occurs rarely in men, accounting for approximately 1% of all breast carcinomas. Data on prognosis principally derive from retrospective studies and from extrapolation of female breast cancer series. Patients and Methods: A total of 99 men with invasive breast cancer were matched with 198 women with breast cancer who had surgery at the same institution from 1999 to 2010. Matching variables were year of surgery, age, primary tumor size, nodal involvement, hormone receptor status, status of HER2 (human epidermal growth factor receptor 2 [ERBB2]), Ki-67, and grade. Median follow-up was 8.6 years. Results: Disease-free survival (DFS) was significantly poorer in the men (10-year DFS, 51.7% vs. 66.5%; hazard ratio [HR], 1.79; 95% CI, 1.19-2.68; P = .004). Similar results were observed for overall survival (OS) (10-year OS, 70.7% vs. 84.2%; HR, 1.79; 95% CI, 1.01-3.15; P = .043). The cumulative incidence of death for causes not related to the primary breast cancer was significantly higher for men than for women (HR, 2.87; 95% CI, 1.58-5.22; P = .001), whereas the breast cancerespecific survival (BCSS) was similar between the 2 groups (10-year BCSS, 81.5% vs. 88%; HR, 1.27; 95% CI, 0.62-2.59; P = .517). Conclusion: This comparative series found that men with breast cancer had a poorer DFS and OS when compared with women. The men also had a higher risk of contralateral tumors and second primaries. Appropriate counseling, surveillance, and prevention are recommended to improve survival for these individuals.
KW - Counseling
KW - Men
KW - Prevention
KW - Second primaries
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84922664337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922664337&partnerID=8YFLogxK
U2 - 10.1016/j.clbc.2014.02.008
DO - 10.1016/j.clbc.2014.02.008
M3 - Article
C2 - 24742826
AN - SCOPUS:84922664337
VL - 14
SP - 371
EP - 377
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
SN - 1526-8209
IS - 5
ER -