Outcome of pancreaticoduodenectomy in octogenarians: Single institution's experience and review of the literature

V. Beltrame, M. Gruppo, D. Pastorelli, S. Pedrazzoli, S. Merigliano, C. Sperti

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

INTRODUCTION: Pancreatic and perampullary neoplasms in patients aged 80 or older trouble the surgeons because of the risk of surgical treatment. We have reviewed our experience and literature's reports of pancreaticoduodenectomy in octogenarians, evaluating early results and long-term survival in pancreatic cancer group.

METHODS: Three hundred eighty-five patients who underwent pancreaticoduodenectomy for neoplasms from 1998 to 2011 were included in the study, and were divided in two groups: group 1, patients younger than 80 years of age, and group 2, patients 80 years of age and older. Operative morbidity, mortality, disease-free and long-term survival were analysed. English literature was systematically searched for pancreatic resection's outcome in octogenarians.

RESULTS: There were 385 pancreaticoduodenectomies: 362 patients were in group 1 and 23 patients in group 2. There was no significant difference regarding gender, and pathologic findings between the two groups. Complications' rate (40 vs. 43%), mortality rate (4% vs. 0%), and overall median survival for pancreatic cancer patients were not statistically different in the two groups (median 21 vs. 19 months). Literature's review showed 14 reports of pancreatic resection in octogenarians. Most of the studies (particularly in centres with high-volume pancreatic surgery) showed that outcome after pancreatectomy was not different in octogenarians or in younger patients.

CONCLUSION: Pancreaticoduodenectomy is an acceptable option for elderly patients. Age alone should not be considered a contraindication to major pancreatic resection, but a careful preoperative evaluation and an accurate postoperative management are mandatory.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalJournal of visceral surgery
Volume152
Issue number5
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Pancreaticoduodenectomy
Pancreatic Neoplasms
Survival
Literature
Pancreatectomy
Mortality
Age Groups
Morbidity

Keywords

  • Octogenarians
  • Pancreas
  • Pancreatectomy
  • Pancreatic neoplasms
  • Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Outcome of pancreaticoduodenectomy in octogenarians : Single institution's experience and review of the literature. / Beltrame, V.; Gruppo, M.; Pastorelli, D.; Pedrazzoli, S.; Merigliano, S.; Sperti, C.

In: Journal of visceral surgery, Vol. 152, No. 5, 01.11.2015, p. 279-284.

Research output: Contribution to journalArticle

Beltrame, V. ; Gruppo, M. ; Pastorelli, D. ; Pedrazzoli, S. ; Merigliano, S. ; Sperti, C. / Outcome of pancreaticoduodenectomy in octogenarians : Single institution's experience and review of the literature. In: Journal of visceral surgery. 2015 ; Vol. 152, No. 5. pp. 279-284.
@article{86c63b97f9d5444eb24d203898a5ab33,
title = "Outcome of pancreaticoduodenectomy in octogenarians: Single institution's experience and review of the literature",
abstract = "INTRODUCTION: Pancreatic and perampullary neoplasms in patients aged 80 or older trouble the surgeons because of the risk of surgical treatment. We have reviewed our experience and literature's reports of pancreaticoduodenectomy in octogenarians, evaluating early results and long-term survival in pancreatic cancer group.METHODS: Three hundred eighty-five patients who underwent pancreaticoduodenectomy for neoplasms from 1998 to 2011 were included in the study, and were divided in two groups: group 1, patients younger than 80 years of age, and group 2, patients 80 years of age and older. Operative morbidity, mortality, disease-free and long-term survival were analysed. English literature was systematically searched for pancreatic resection's outcome in octogenarians.RESULTS: There were 385 pancreaticoduodenectomies: 362 patients were in group 1 and 23 patients in group 2. There was no significant difference regarding gender, and pathologic findings between the two groups. Complications' rate (40 vs. 43{\%}), mortality rate (4{\%} vs. 0{\%}), and overall median survival for pancreatic cancer patients were not statistically different in the two groups (median 21 vs. 19 months). Literature's review showed 14 reports of pancreatic resection in octogenarians. Most of the studies (particularly in centres with high-volume pancreatic surgery) showed that outcome after pancreatectomy was not different in octogenarians or in younger patients.CONCLUSION: Pancreaticoduodenectomy is an acceptable option for elderly patients. Age alone should not be considered a contraindication to major pancreatic resection, but a careful preoperative evaluation and an accurate postoperative management are mandatory.",
keywords = "Octogenarians, Pancreas, Pancreatectomy, Pancreatic neoplasms, Survival",
author = "V. Beltrame and M. Gruppo and D. Pastorelli and S. Pedrazzoli and S. Merigliano and C. Sperti",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.jviscsurg.2015.06.004",
language = "English",
volume = "152",
pages = "279--284",
journal = "Journal of visceral surgery",
issn = "1878-7886",
publisher = "Elsevier Masson",
number = "5",

}

TY - JOUR

T1 - Outcome of pancreaticoduodenectomy in octogenarians

T2 - Single institution's experience and review of the literature

AU - Beltrame, V.

AU - Gruppo, M.

AU - Pastorelli, D.

AU - Pedrazzoli, S.

AU - Merigliano, S.

AU - Sperti, C.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - INTRODUCTION: Pancreatic and perampullary neoplasms in patients aged 80 or older trouble the surgeons because of the risk of surgical treatment. We have reviewed our experience and literature's reports of pancreaticoduodenectomy in octogenarians, evaluating early results and long-term survival in pancreatic cancer group.METHODS: Three hundred eighty-five patients who underwent pancreaticoduodenectomy for neoplasms from 1998 to 2011 were included in the study, and were divided in two groups: group 1, patients younger than 80 years of age, and group 2, patients 80 years of age and older. Operative morbidity, mortality, disease-free and long-term survival were analysed. English literature was systematically searched for pancreatic resection's outcome in octogenarians.RESULTS: There were 385 pancreaticoduodenectomies: 362 patients were in group 1 and 23 patients in group 2. There was no significant difference regarding gender, and pathologic findings between the two groups. Complications' rate (40 vs. 43%), mortality rate (4% vs. 0%), and overall median survival for pancreatic cancer patients were not statistically different in the two groups (median 21 vs. 19 months). Literature's review showed 14 reports of pancreatic resection in octogenarians. Most of the studies (particularly in centres with high-volume pancreatic surgery) showed that outcome after pancreatectomy was not different in octogenarians or in younger patients.CONCLUSION: Pancreaticoduodenectomy is an acceptable option for elderly patients. Age alone should not be considered a contraindication to major pancreatic resection, but a careful preoperative evaluation and an accurate postoperative management are mandatory.

AB - INTRODUCTION: Pancreatic and perampullary neoplasms in patients aged 80 or older trouble the surgeons because of the risk of surgical treatment. We have reviewed our experience and literature's reports of pancreaticoduodenectomy in octogenarians, evaluating early results and long-term survival in pancreatic cancer group.METHODS: Three hundred eighty-five patients who underwent pancreaticoduodenectomy for neoplasms from 1998 to 2011 were included in the study, and were divided in two groups: group 1, patients younger than 80 years of age, and group 2, patients 80 years of age and older. Operative morbidity, mortality, disease-free and long-term survival were analysed. English literature was systematically searched for pancreatic resection's outcome in octogenarians.RESULTS: There were 385 pancreaticoduodenectomies: 362 patients were in group 1 and 23 patients in group 2. There was no significant difference regarding gender, and pathologic findings between the two groups. Complications' rate (40 vs. 43%), mortality rate (4% vs. 0%), and overall median survival for pancreatic cancer patients were not statistically different in the two groups (median 21 vs. 19 months). Literature's review showed 14 reports of pancreatic resection in octogenarians. Most of the studies (particularly in centres with high-volume pancreatic surgery) showed that outcome after pancreatectomy was not different in octogenarians or in younger patients.CONCLUSION: Pancreaticoduodenectomy is an acceptable option for elderly patients. Age alone should not be considered a contraindication to major pancreatic resection, but a careful preoperative evaluation and an accurate postoperative management are mandatory.

KW - Octogenarians

KW - Pancreas

KW - Pancreatectomy

KW - Pancreatic neoplasms

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=84984549329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984549329&partnerID=8YFLogxK

U2 - 10.1016/j.jviscsurg.2015.06.004

DO - 10.1016/j.jviscsurg.2015.06.004

M3 - Article

C2 - 26117303

AN - SCOPUS:84984549329

VL - 152

SP - 279

EP - 284

JO - Journal of visceral surgery

JF - Journal of visceral surgery

SN - 1878-7886

IS - 5

ER -