Outcome of patients activating an unrelated donor search for severe acquired aplastic anemia

Sébastien Maury, Marie Lorraine Balère-Appert, Simona Pollichieni, Rosi Oneto, Ibrahim Yakoub-Agha, Franco Locatelli, Jean Hugues Dalle, Edoardo Lanino, Alain Fischer, Andrea Pession, Anne Huynh, Walter Barberi, Mohamad Mohty, Antonio Risitano, Noel Milpied, Gérard Socié, Andrea Bacigalupo, Judith Marsh, Jakob R. Passweg

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with severe aplastic anemia (SAA) without a sibling donor receive immunosuppressive treatment (IST) with anti-thymocyte globulin (ATG). In the case of no response to IST, a voluntary unrelated donor (VUD) search is usually started. This study analyzes the outcome of ATG-refractory SAA patients activating a VUD search. Of 179 patients, 68 had at least one HLA-A, -B, and -DR matched donor identified and underwent HSCT while 50 also with a donor were not transplanted because of early death (8), late response to IST (34), transplant refusal (1), or other (7). Conversely, 61 had no matched donor, 13 of those ultimately received a mismatched HSCT. All but one received marrow stem cells. Among patients aged

Original languageEnglish
Pages (from-to)868-873
Number of pages6
JournalAmerican Journal of Hematology
Volume88
Issue number10
DOIs
Publication statusPublished - Oct 2013

ASJC Scopus subject areas

  • Hematology

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