Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead

Gianluigi Bencardino, Antonio Di Monaco, Eleonora Russo, Cristian Colizzi, Francesco Perna, Gemma Pelargonio, Maria Lucia Narducci, Francesca Augusta Gabrielli, Gaetano Lanza, A. G. Rebuzzi, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Background: Not all heart failure (HF) patients benefit from cardiac resynchronization therapy (CRT). We assessed whether choosing the site of left ventricular (LV) pacing by a quadripolar lead may improve response to CRT. Methods and Results: We prospectively randomized 23 patients with HF (67±11 years; 21 males) to CRT with a quadripolar LV lead (group 1, with the LV pacing site chosen on the basis of QRS shortening using simultaneous biventricular pacing), and 20 patients (71±6 years; 16 males) to a bipolar LV lead (group 2, with devices programmed with a conventional tip-to-ring configuration). New York Heart Association (NYHA) class and LV ejection fraction (EF) by 2D echocardiography were assessed at baseline and after 3 months. The baseline EF was not different between the 2 groups (25±6% group 1 vs. 27±3% group 2; P=0.22), but after 3 months EF was higher in group 1 (35±13% group 1 vs. 31±4% group 2; P

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalCirculation Journal
Volume80
Issue number3
DOIs
Publication statusPublished - Feb 25 2016

Keywords

  • Cardiac resynchronization therapy
  • Heart failure
  • Mortality
  • Multipolar pacing
  • Quadripolar lead

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Bencardino, G., Di Monaco, A., Russo, E., Colizzi, C., Perna, F., Pelargonio, G., Narducci, M. L., Gabrielli, F. A., Lanza, G., Rebuzzi, A. G., & Crea, F. (2016). Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead. Circulation Journal, 80(3), 613-618. https://doi.org/10.1253/circj.CJ-15-0932