Abstract
Background: Not all heart failure (HF) patients benefit from cardiac resynchronization therapy (CRT). We assessed whether choosing the site of left ventricular (LV) pacing by a quadripolar lead may improve response to CRT. Methods and Results: We prospectively randomized 23 patients with HF (67±11 years; 21 males) to CRT with a quadripolar LV lead (group 1, with the LV pacing site chosen on the basis of QRS shortening using simultaneous biventricular pacing), and 20 patients (71±6 years; 16 males) to a bipolar LV lead (group 2, with devices programmed with a conventional tip-to-ring configuration). New York Heart Association (NYHA) class and LV ejection fraction (EF) by 2D echocardiography were assessed at baseline and after 3 months. The baseline EF was not different between the 2 groups (25±6% group 1 vs. 27±3% group 2; P=0.22), but after 3 months EF was higher in group 1 (35±13% group 1 vs. 31±4% group 2; P
Original language | English |
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Pages (from-to) | 613-618 |
Number of pages | 6 |
Journal | Circulation Journal |
Volume | 80 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 25 2016 |
Keywords
- Cardiac resynchronization therapy
- Heart failure
- Mortality
- Multipolar pacing
- Quadripolar lead
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine