Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead

Gianluigi Bencardino; Antonio Di Monaco; Eleonora Russo; Cristian Colizzi; Francesco Perna; Gemma Pelargonio; Maria Lucia Narducci; Francesca Augusta Gabrielli; Gaetano Lanza; A. G. Rebuzzi; Filippo Crea

doi:10.1253/circj.CJ-15-0932

Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead

Gianluigi Bencardino, Antonio Di Monaco, Eleonora Russo, Cristian Colizzi, Francesco Perna, Gemma Pelargonio, Maria Lucia Narducci, Francesca Augusta Gabrielli, Gaetano Lanza, A. G. Rebuzzi, Filippo Crea

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Not all heart failure (HF) patients benefit from cardiac resynchronization therapy (CRT). We assessed whether choosing the site of left ventricular (LV) pacing by a quadripolar lead may improve response to CRT. Methods and Results: We prospectively randomized 23 patients with HF (67±11 years; 21 males) to CRT with a quadripolar LV lead (group 1, with the LV pacing site chosen on the basis of QRS shortening using simultaneous biventricular pacing), and 20 patients (71±6 years; 16 males) to a bipolar LV lead (group 2, with devices programmed with a conventional tip-to-ring configuration). New York Heart Association (NYHA) class and LV ejection fraction (EF) by 2D echocardiography were assessed at baseline and after 3 months. The baseline EF was not different between the 2 groups (25±6% group 1 vs. 27±3% group 2; P=0.22), but after 3 months EF was higher in group 1 (35±13% group 1 vs. 31±4% group 2; P

Original language	English
Pages (from-to)	613-618
Number of pages	6
Journal	Circulation Journal
Volume	80
Issue number	3
DOIs	https://doi.org/10.1253/circj.CJ-15-0932
Publication status	Published - Feb 25 2016

Keywords

Cardiac resynchronization therapy
Heart failure
Mortality
Multipolar pacing
Quadripolar lead

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-15-0932

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Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead. / Bencardino, Gianluigi; Di Monaco, Antonio; Russo, Eleonora; Colizzi, Cristian; Perna, Francesco; Pelargonio, Gemma; Narducci, Maria Lucia; Gabrielli, Francesca Augusta; Lanza, Gaetano; Rebuzzi, A. G.; Crea, Filippo.

In: Circulation Journal, Vol. 80, No. 3, 25.02.2016, p. 613-618.

Research output: Contribution to journal › Article › peer-review

Bencardino, Gianluigi ; Di Monaco, Antonio ; Russo, Eleonora ; Colizzi, Cristian ; Perna, Francesco ; Pelargonio, Gemma ; Narducci, Maria Lucia ; Gabrielli, Francesca Augusta ; Lanza, Gaetano ; Rebuzzi, A. G. ; Crea, Filippo. / Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead. In: Circulation Journal. 2016 ; Vol. 80, No. 3. pp. 613-618.

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AU - Perna, Francesco

AU - Pelargonio, Gemma

AU - Narducci, Maria Lucia

AU - Gabrielli, Francesca Augusta

AU - Lanza, Gaetano

AU - Rebuzzi, A. G.

AU - Crea, Filippo

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N2 - Background: Not all heart failure (HF) patients benefit from cardiac resynchronization therapy (CRT). We assessed whether choosing the site of left ventricular (LV) pacing by a quadripolar lead may improve response to CRT. Methods and Results: We prospectively randomized 23 patients with HF (67±11 years; 21 males) to CRT with a quadripolar LV lead (group 1, with the LV pacing site chosen on the basis of QRS shortening using simultaneous biventricular pacing), and 20 patients (71±6 years; 16 males) to a bipolar LV lead (group 2, with devices programmed with a conventional tip-to-ring configuration). New York Heart Association (NYHA) class and LV ejection fraction (EF) by 2D echocardiography were assessed at baseline and after 3 months. The baseline EF was not different between the 2 groups (25±6% group 1 vs. 27±3% group 2; P=0.22), but after 3 months EF was higher in group 1 (35±13% group 1 vs. 31±4% group 2; P

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Outcome of patients treated by cardiac resynchronization therapy using a quadripolar left ventricular lead

Abstract

Keywords

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