Outcome of Patients with Cancer of the Esophagogastric Junction in relation to Histology and Surgical Strategy

Luca Gianotti, Marco Braga, Luca Landoni, Gilberto Mari, Francesca Scaltrini, Augusto Di Castelnuovo, Valerio Di Carlo

Research output: Contribution to journalArticle

Abstract

Background/Aims: The impact of histologic type and surgical strategy on survival of patients with cancer of the esophagogastric junction is debated. Thus, we evaluated the relationship between cancer histologic type (adenocarcinoma vs. squamous cell carcinoma) on long-term survival and the results of two different surgical techniques on outcome. Methodology: Two hundred and one patients with neoplasm of the esophagogastric junction were prospectively observed, and 133 patients (66%) underwent operation with curative intent. The results of two resective techniques, total gastrectomy with a thoraco-abdominal approach and total gastrectomy with a trans-hiatal approach were also compared in a subgroup with Siewert's type II and III cancer. Results: Seventy-seven patients had an adenocarcinoma and 56 a squamous cell carcinoma. The 5-year proportion of survival was 35% in the adenocarcinoma group versus 40% in the squamous group (logrank=0.92), and the mean length of survival was 35±3 months and 34±5 months, respectively. The overall incidence of postoperative morbidity and the length of hospital stay were both significantly lower in the trans-hiatal group than in the thoraco-abdominal group (31% vs. 51%; p=0.04; and 15.6 days vs. 23.2 days; p=0.02 respectively), while the 5-year patient survival was 37% thoraco-abdominal approach and 42% in the trans-hiatal approach (logrank=0.62). Conclusions: In the present population, histologic type of the esophagogastric cancer was not a determinant factor for long-term survival. The trans-hiatal approach resulted in a better postoperative outcome without compromising surgical radicality and patient survival.

Original languageEnglish
Pages (from-to)1948-1952
Number of pages5
JournalHepato-Gastroenterology
Volume50
Issue number54
Publication statusPublished - Nov 2003

Keywords

  • Cancer
  • Esophagogastric junction
  • Histology
  • Morbidity
  • Outcome
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Outcome of Patients with Cancer of the Esophagogastric Junction in relation to Histology and Surgical Strategy'. Together they form a unique fingerprint.

  • Cite this

    Gianotti, L., Braga, M., Landoni, L., Mari, G., Scaltrini, F., Di Castelnuovo, A., & Di Carlo, V. (2003). Outcome of Patients with Cancer of the Esophagogastric Junction in relation to Histology and Surgical Strategy. Hepato-Gastroenterology, 50(54), 1948-1952.