Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy

Filippo Montemurro, Michela Donadio, Matteo Clavarezza, Stefania Redana, Maria Elena Jacomuzzi, Giorgio Valabrega, Saverio Danese, Guido Vietti-Ramus, Antonio Durando, Marco Venturini, Massimo Aglietta

Research output: Contribution to journalArticlepeer-review

Abstract

We sought to describe patterns of treatment and clinical outcome in patients with HER2-positive advanced breast cancer progressing on trastuzumab-based therapy. One hundred eighty-four consecutive HER2-positive advanced breast cancer patients received trastuzumab-based therapy between September 1999 and September 2004. Patients were followed up until death or May 2005. For patients progressing on trastuzumab-based therapy, we calculated the response rate (RR) to the first post-progression treatment, overall survival (OS) from the first administration of trastuzumab, time to second progression (TT-SP), and post-progression survival (PPS), according to treatment. At the time of this analysis, 132 patients had progressed on trastuzumab-based therapy, and 89 had died. Of the progressing patients, 21 experienced rapid progression and could not receive additional anticancer treatments; 40 patients continued trastuzumab either alone (12 patients with isolated central nervous system progression), with chemotherapy (23 patients), or with endocrine therapy (5 patients); and 71 stopped trastuzumab and received chemotherapy (61 patients) or endocrine therapy (10 patients) as the first post-progression treatment. Excluding patients with rapid progression, clinical outcomes were similar whether trastuzumab was continued or not, in terms of RR (18% and 27%, respectively), OS (31 and 30 months, respectively), TT-SP (6 and 7 months, respectively), and PPS (21 and 19 months, respectively). The clinical outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy might not be influenced by continuing trastuzumab. The optimal therapeutic strategy in this setting of patients needs evaluation in randomized trials.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalThe oncologist
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2006

Keywords

  • HER2
  • Metastatic breast cancer
  • Survival
  • Time to progression
  • Trastuzumab
  • Tumor progression

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

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