Outcome of relapse after allogeneic stem cell transplant in patients with acute myeloid leukemia

Raynier Devillier, Roberto Crocchiolo, Anne Etienne, Thomas Prebet, Aude Charbonnier, Sabine Fürst, Jean El-Cheikh, Evelyne D'Incan, Jérôme Rey, Catherine Faucher, Didier Blaise, Norbert Vey

Research output: Contribution to journalArticlepeer-review

Abstract

Although allogeneic stem cell transplant (Allo-SCT) is an effective treatment for high-risk acute myeloid leukemia (AML), relapses remain a major cause of treatment failure. There is currently no standard of care for post-transplant relapse of AML, but the increasing numbers of investigational agents in this setting require a better knowledge of their outcome. We retrospectively evaluated the efficacy of salvage therapies in 54 patients with AML relapsing after Allo-SCT. Twenty-four patients received intensive salvage treatment (17 non-intensive chemotherapy, 13 supportive care). Complete remissions (CRs) were seen only in the group who received intensive salvage (CR rate: 17/24 [71%]). One-year overall survival was 19% (median: 3.4 months) in the whole study group and 33% in the intensive savage group (vs. 7% for patients without intensive salvage, p = 0.004). Factors influencing overall survival (OS) were: time to relapse after Allo-SCT (hazard ratio [HR]: 3.7 [1.6-8.8]) and performance status (PS) at relapse (HR: 2.2 [1.1-4.4]) by multivariate analysis. Our results confirm the poor prognosis of AML relapse after Allo-SCT. In selected patients salvage chemotherapy produces CRs, but these are short lived. Other strategies aiming at modulating immune antileukemic activity have to be developed.

Original languageEnglish
Pages (from-to)1228-1234
Number of pages7
JournalLeukemia and Lymphoma
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Acute myeloid leukemia
  • Allogeneic stem cell transplantation
  • Relapse

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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