Outcome of T1N0M0 breast cancer in relation to St. Gallen risk assignment criteria for adjuvant therapy

I. Garassino; G. Gullo; S. Orefice; L. Tondulli; G. Masci; P. Salvini; M. Eboli; L. Di Tommaso; L. Giordano; M. Alloisio; M. Roncalli; A. Santoro

doi:10.1016/j.breast.2009.07.003

Outcome of T1N0M0 breast cancer in relation to St. Gallen risk assignment criteria for adjuvant therapy

I. Garassino, G. Gullo, S. Orefice, L. Tondulli, G. Masci, P. Salvini, M. Eboli, L. Di Tommaso, L. Giordano, M. Alloisio, M. Roncalli, A. Santoro

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

T1N0M0 (stage I) breast cancer (BC) has been increasing in recent decades but the optimal adjuvant approach remains controversial. To assess the outcome of BC patients stratified and treated with multimodal therapies according to St. Gallen consensus meeting recommendations, we retrospectively evaluated an unselected cohort of T1N0M0 BC patients, with respect to the St. Gallen criteria. At a median follow-up of 5 years, the recurrence rate, recurrence-free survival and overall survival were 7%, 94% and 96% respectively, and 60% of relapses were locoregional. No statistically significant difference was observed between T1a,b/T1c groups, or among risk categories (high/intermediate/low). The very low rate of distant recurrences even in patients with unfavorable prognostic factors seems to support the use of adjuvant systemic therapies but better prognostic and predictive factors are strongly needed for this subset of patients.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Breast
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.breast.2009.07.003
Publication status	Published - Aug 2009

Keywords

Adjuvant therapy
Conservative surgery
Early breast cancer
Prognostic factors
St. Gallen consensus meeting
Stage I breast cancer

ASJC Scopus subject areas

Surgery

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Outcome of T1N0M0 breast cancer in relation to St. Gallen risk assignment criteria for adjuvant therapy. / Garassino, I.; Gullo, G.; Orefice, S.; Tondulli, L.; Masci, G.; Salvini, P.; Eboli, M.; Di Tommaso, L.; Giordano, L.; Alloisio, M.; Roncalli, M.; Santoro, A.

In: Breast, Vol. 18, No. 4, 08.2009, p. 263-266.

Research output: Contribution to journal › Article › peer-review

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abstract = "T1N0M0 (stage I) breast cancer (BC) has been increasing in recent decades but the optimal adjuvant approach remains controversial. To assess the outcome of BC patients stratified and treated with multimodal therapies according to St. Gallen consensus meeting recommendations, we retrospectively evaluated an unselected cohort of T1N0M0 BC patients, with respect to the St. Gallen criteria. At a median follow-up of 5 years, the recurrence rate, recurrence-free survival and overall survival were 7%, 94% and 96% respectively, and 60% of relapses were locoregional. No statistically significant difference was observed between T1a,b/T1c groups, or among risk categories (high/intermediate/low). The very low rate of distant recurrences even in patients with unfavorable prognostic factors seems to support the use of adjuvant systemic therapies but better prognostic and predictive factors are strongly needed for this subset of patients.",

keywords = "Adjuvant therapy, Conservative surgery, Early breast cancer, Prognostic factors, St. Gallen consensus meeting, Stage I breast cancer",

author = "I. Garassino and G. Gullo and S. Orefice and L. Tondulli and G. Masci and P. Salvini and M. Eboli and {Di Tommaso}, L. and L. Giordano and M. Alloisio and M. Roncalli and A. Santoro",

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doi = "10.1016/j.breast.2009.07.003",

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AU - Garassino, I.

AU - Gullo, G.

AU - Orefice, S.

AU - Tondulli, L.

AU - Masci, G.

AU - Salvini, P.

AU - Eboli, M.

AU - Di Tommaso, L.

AU - Giordano, L.

AU - Alloisio, M.

AU - Roncalli, M.

AU - Santoro, A.

PY - 2009/8

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N2 - T1N0M0 (stage I) breast cancer (BC) has been increasing in recent decades but the optimal adjuvant approach remains controversial. To assess the outcome of BC patients stratified and treated with multimodal therapies according to St. Gallen consensus meeting recommendations, we retrospectively evaluated an unselected cohort of T1N0M0 BC patients, with respect to the St. Gallen criteria. At a median follow-up of 5 years, the recurrence rate, recurrence-free survival and overall survival were 7%, 94% and 96% respectively, and 60% of relapses were locoregional. No statistically significant difference was observed between T1a,b/T1c groups, or among risk categories (high/intermediate/low). The very low rate of distant recurrences even in patients with unfavorable prognostic factors seems to support the use of adjuvant systemic therapies but better prognostic and predictive factors are strongly needed for this subset of patients.

AB - T1N0M0 (stage I) breast cancer (BC) has been increasing in recent decades but the optimal adjuvant approach remains controversial. To assess the outcome of BC patients stratified and treated with multimodal therapies according to St. Gallen consensus meeting recommendations, we retrospectively evaluated an unselected cohort of T1N0M0 BC patients, with respect to the St. Gallen criteria. At a median follow-up of 5 years, the recurrence rate, recurrence-free survival and overall survival were 7%, 94% and 96% respectively, and 60% of relapses were locoregional. No statistically significant difference was observed between T1a,b/T1c groups, or among risk categories (high/intermediate/low). The very low rate of distant recurrences even in patients with unfavorable prognostic factors seems to support the use of adjuvant systemic therapies but better prognostic and predictive factors are strongly needed for this subset of patients.

KW - Adjuvant therapy

KW - Conservative surgery

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KW - Prognostic factors

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