Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL)

on behalf of Fondazione Italiana Linfomi (FIL)

doi:10.1111/bjh.15816

Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL)

on behalf of Fondazione Italiana Linfomi (FIL)

Research output: Contribution to journal › Article › peer-review

Abstract

Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P < 0·001). In Group 1, 5-year progression-free survival was superior after rituximab maintenance compared to observation only (94% vs. 53%, P = 0·024). In Group 2, an inverse trend was found between survival and both a higher number of pre-transformation treatment lines and a short time-to-transformation.

Original language	English
Pages (from-to)	713-717
Number of pages	5
Journal	British Journal of Haematology
Volume	185
Issue number	4
DOIs	https://doi.org/10.1111/bjh.15816
Publication status	Published - May 1 2019

Keywords

autologous stem cell transplantation
composite lymphoma
follicular lymphoma
histological transformation
rituximab maintenance

ASJC Scopus subject areas

Hematology

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10.1111/bjh.15816

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Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL). / on behalf of Fondazione Italiana Linfomi (FIL).

In: British Journal of Haematology, Vol. 185, No. 4, 01.05.2019, p. 713-717.

Research output: Contribution to journal › Article › peer-review

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abstract = "Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P < 0·001). In Group 1, 5-year progression-free survival was superior after rituximab maintenance compared to observation only (94% vs. 53%, P = 0·024). In Group 2, an inverse trend was found between survival and both a higher number of pre-transformation treatment lines and a short time-to-transformation.",

keywords = "autologous stem cell transplantation, composite lymphoma, follicular lymphoma, histological transformation, rituximab maintenance",

author = "{on behalf of Fondazione Italiana Linfomi (FIL)} and Chiara Rusconi and Antonella Anastasia and Annalisa Chiarenza and Luigi Marcheselli and Federica Cavallo and Sara Rattotti and Barbara Botto and Angela Ferrari and Luca Nassi and Chiara Pagani and Erika Meli and Luca Arcaini and Massimo Federico and Giuseppe Rossi",

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doi = "10.1111/bjh.15816",

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AU - on behalf of Fondazione Italiana Linfomi (FIL)

AU - Rusconi, Chiara

AU - Anastasia, Antonella

AU - Chiarenza, Annalisa

AU - Marcheselli, Luigi

AU - Cavallo, Federica

AU - Rattotti, Sara

AU - Botto, Barbara

AU - Ferrari, Angela

AU - Nassi, Luca

AU - Pagani, Chiara

AU - Meli, Erika

AU - Arcaini, Luca

AU - Federico, Massimo

AU - Rossi, Giuseppe

PY - 2019/5/1

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AB - Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P < 0·001). In Group 1, 5-year progression-free survival was superior after rituximab maintenance compared to observation only (94% vs. 53%, P = 0·024). In Group 2, an inverse trend was found between survival and both a higher number of pre-transformation treatment lines and a short time-to-transformation.

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KW - composite lymphoma

KW - follicular lymphoma

KW - histological transformation

KW - rituximab maintenance

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Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL)

Abstract

Keywords

ASJC Scopus subject areas

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