Abstract
Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P < 0·001). In Group 1, 5-year progression-free survival was superior after rituximab maintenance compared to observation only (94% vs. 53%, P = 0·024). In Group 2, an inverse trend was found between survival and both a higher number of pre-transformation treatment lines and a short time-to-transformation.
| Original language | English |
|---|---|
| Pages (from-to) | 713-717 |
| Number of pages | 5 |
| Journal | British Journal of Haematology |
| Volume | 185 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - May 1 2019 |
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Keywords
- autologous stem cell transplantation
- composite lymphoma
- follicular lymphoma
- histological transformation
- rituximab maintenance
ASJC Scopus subject areas
- Hematology
Cite this
Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL). / on behalf of Fondazione Italiana Linfomi (FIL).
In: British Journal of Haematology, Vol. 185, No. 4, 01.05.2019, p. 713-717.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL)
AU - on behalf of Fondazione Italiana Linfomi (FIL)
AU - Rusconi, Chiara
AU - Anastasia, Antonella
AU - Chiarenza, Annalisa
AU - Marcheselli, Luigi
AU - Cavallo, Federica
AU - Rattotti, Sara
AU - Botto, Barbara
AU - Ferrari, Angela
AU - Nassi, Luca
AU - Pagani, Chiara
AU - Meli, Erika
AU - Arcaini, Luca
AU - Federico, Massimo
AU - Rossi, Giuseppe
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P < 0·001). In Group 1, 5-year progression-free survival was superior after rituximab maintenance compared to observation only (94% vs. 53%, P = 0·024). In Group 2, an inverse trend was found between survival and both a higher number of pre-transformation treatment lines and a short time-to-transformation.
AB - Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P < 0·001). In Group 1, 5-year progression-free survival was superior after rituximab maintenance compared to observation only (94% vs. 53%, P = 0·024). In Group 2, an inverse trend was found between survival and both a higher number of pre-transformation treatment lines and a short time-to-transformation.
KW - autologous stem cell transplantation
KW - composite lymphoma
KW - follicular lymphoma
KW - histological transformation
KW - rituximab maintenance
UR - http://www.scopus.com/inward/record.url?scp=85065255314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065255314&partnerID=8YFLogxK
U2 - 10.1111/bjh.15816
DO - 10.1111/bjh.15816
M3 - Article
C2 - 30793297
AN - SCOPUS:85065255314
VL - 185
SP - 713
EP - 717
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 4
ER -