Outcome of transformed follicular lymphoma worsens according to the timing of transformation and to the number of previous therapies. A retrospective multicenter study on behalf of Fondazione Italiana Linfomi (FIL)

C. Rusconi, A. Anastasia, A. Chiarenza, L. Marcheselli, F. Cavallo, S. Rattotti, B. Botto, A. Ferrari, L. Nassi, C. Pagani, E. Meli, L. Arcaini, M. Federico, G. Rossi, on behalf of Fondazione Italiana Linfomi (FIL)

Research output: Contribution to journalArticlepeer-review

Abstract

Optimal treatment for transformed follicular lymphoma (tFL) is not fully defined. Clinical characteristics and treatments that impact on post-transformation outcome of 176 biopsy-proven tFL were analysed. Transformation occurred at initial diagnosis in 52% (Group 1) and after a FL diagnosis in 48% (Group 2). Five-year overall survival was 84% for Group 1 and 51% for Group 2 (P 
Original languageEnglish
Pages (from-to)713-717
Number of pages5
JournalBr. J. Haematol.
Volume185
Issue number4
DOIs
Publication statusPublished - May 1 2019

Keywords

  • autologous stem cell transplantation
  • composite lymphoma
  • follicular lymphoma
  • histological transformation
  • rituximab maintenance
  • anthracycline derivative
  • rituximab
  • Article
  • cancer prognosis
  • cancer survival
  • cell transformation
  • human
  • human tissue
  • major clinical study
  • multicenter study
  • outcome assessment
  • overall survival
  • priority journal
  • probability
  • progression free survival
  • proportional hazards model
  • retrospective study

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