Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†

Riccardo Cocchieri; Rainer Petzina; Mauro Romano; Dariusz Jagielak; Nikolaos Bonaros; Marco Aiello; Joel Lapeze; Mika Laine; Sidney Chocron; Douglas Muir; Walter Eichinger; Matthias Thielmann; Louis Labrousse; Kjell Arne Rein; Jean-Philippe Verhoye; Gino Gerosa; Vinayak Bapat; Hardy Baumbach; Helen Sims; Cornelia Deutsch; Peter Bramlage; Jana Kurucova; Martin Thoenes; Derk Frank

doi:10.1093/ejcts/ezy333

Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†

Riccardo Cocchieri, Rainer Petzina, Mauro Romano, Dariusz Jagielak, Nikolaos Bonaros, Marco Aiello, Joel Lapeze, Mika Laine, Sidney Chocron, Douglas Muir, Walter Eichinger, Matthias Thielmann, Louis Labrousse, Kjell Arne Rein, Jean-Philippe Verhoye, Gino Gerosa, Vinayak Bapat, Hardy Baumbach, Helen Sims, Cornelia DeutschPeter Bramlage, Jana Kurucova, Martin Thoenes, Derk Frank

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: There is lack of data regarding the longer-term outcomes of patients undergoing transaortic (TAo) transcatheter aortic valve implantation (TAVI). We aimed to provide a contemporary snapshot of the types and frequencies of events in the year following TAo-TAVI. METHODS: The Registry of the Utilization of the TAo-TAVI approach using the Edwards SAPIEN Valve (ROUTE) is a multicentre, European, prospective, observational registry of aortic stenosis patients undergoing TAo-TAVI. Patients were grouped according to the composite end point death, myocardial infarction, stroke/transient ischaemic attack, major vascular complications, life-threatening bleeding, acute kidney injury (AKI) and/or cardiovascular rehospitalization. RESULTS: Two hundred and fifty-three patients with a mean age of 81.5 ± 5.8 years were included, of whom 89 (35.2%) patients met the composite end point (the event group) and 164 (64.8%) patients did not (the event-free group). New York Heart Association (NYHA) class III/IV (85.2% vs 71.8%, P = 0.017), Canadian Cardiovascular Society angina class III/IV (22.6% vs 11.4%; P = 0.021), pulmonary disease (32.6% vs 18.9%; P = 0.015) and renal insufficiency (15.7% vs 3.0%; P

Original language	English
Pages (from-to)	737-743
Number of pages	7
Journal	European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Volume	55
Issue number	4
DOIs	https://doi.org/10.1093/ejcts/ezy333
Publication status	Published - Apr 1 2019

Keywords

Balloon-expandable
Follow-up
Mortality
Transaortic
Transcatheter aortic valve implantation

Access to Document

10.1093/ejcts/ezy333

https://pubmed.ncbi.nlm.nih.gov/30346515

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Cocchieri, R., Petzina, R., Romano, M., Jagielak, D., Bonaros, N., Aiello, M., Lapeze, J., Laine, M., Chocron, S., Muir, D., Eichinger, W., Thielmann, M., Labrousse, L., Rein, K. A., Verhoye, J-P., Gerosa, G., Bapat, V., Baumbach, H., Sims, H., ... Frank, D. (2019). Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 55(4), 737-743. https://doi.org/10.1093/ejcts/ezy333

Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†. / Cocchieri, Riccardo; Petzina, Rainer; Romano, Mauro; Jagielak, Dariusz; Bonaros, Nikolaos; Aiello, Marco; Lapeze, Joel; Laine, Mika; Chocron, Sidney; Muir, Douglas; Eichinger, Walter; Thielmann, Matthias; Labrousse, Louis; Rein, Kjell Arne; Verhoye, Jean-Philippe; Gerosa, Gino; Bapat, Vinayak; Baumbach, Hardy; Sims, Helen; Deutsch, Cornelia; Bramlage, Peter; Kurucova, Jana; Thoenes, Martin; Frank, Derk.

In: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 55, No. 4, 01.04.2019, p. 737-743.

Research output: Contribution to journal › Article › peer-review

Cocchieri, R, Petzina, R, Romano, M, Jagielak, D, Bonaros, N, Aiello, M, Lapeze, J, Laine, M, Chocron, S, Muir, D, Eichinger, W, Thielmann, M, Labrousse, L, Rein, KA, Verhoye, J-P, Gerosa, G, Bapat, V, Baumbach, H, Sims, H, Deutsch, C, Bramlage, P, Kurucova, J, Thoenes, M & Frank, D 2019, 'Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†', European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol. 55, no. 4, pp. 737-743. https://doi.org/10.1093/ejcts/ezy333

Cocchieri R, Petzina R, Romano M, Jagielak D, Bonaros N, Aiello M et al. Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2019 Apr 1;55(4):737-743. https://doi.org/10.1093/ejcts/ezy333

Cocchieri, Riccardo ; Petzina, Rainer ; Romano, Mauro ; Jagielak, Dariusz ; Bonaros, Nikolaos ; Aiello, Marco ; Lapeze, Joel ; Laine, Mika ; Chocron, Sidney ; Muir, Douglas ; Eichinger, Walter ; Thielmann, Matthias ; Labrousse, Louis ; Rein, Kjell Arne ; Verhoye, Jean-Philippe ; Gerosa, Gino ; Bapat, Vinayak ; Baumbach, Hardy ; Sims, Helen ; Deutsch, Cornelia ; Bramlage, Peter ; Kurucova, Jana ; Thoenes, Martin ; Frank, Derk. / Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†. In: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2019 ; Vol. 55, No. 4. pp. 737-743.

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title = "Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†",

abstract = "OBJECTIVES: There is lack of data regarding the longer-term outcomes of patients undergoing transaortic (TAo) transcatheter aortic valve implantation (TAVI). We aimed to provide a contemporary snapshot of the types and frequencies of events in the year following TAo-TAVI. METHODS: The Registry of the Utilization of the TAo-TAVI approach using the Edwards SAPIEN Valve (ROUTE) is a multicentre, European, prospective, observational registry of aortic stenosis patients undergoing TAo-TAVI. Patients were grouped according to the composite end point death, myocardial infarction, stroke/transient ischaemic attack, major vascular complications, life-threatening bleeding, acute kidney injury (AKI) and/or cardiovascular rehospitalization. RESULTS: Two hundred and fifty-three patients with a mean age of 81.5 ± 5.8 years were included, of whom 89 (35.2%) patients met the composite end point (the event group) and 164 (64.8%) patients did not (the event-free group). New York Heart Association (NYHA) class III/IV (85.2% vs 71.8%, P = 0.017), Canadian Cardiovascular Society angina class III/IV (22.6% vs 11.4%; P = 0.021), pulmonary disease (32.6% vs 18.9%; P = 0.015) and renal insufficiency (15.7% vs 3.0%; P ",

keywords = "Balloon-expandable, Follow-up, Mortality, Transaortic, Transcatheter aortic valve implantation",

author = "Riccardo Cocchieri and Rainer Petzina and Mauro Romano and Dariusz Jagielak and Nikolaos Bonaros and Marco Aiello and Joel Lapeze and Mika Laine and Sidney Chocron and Douglas Muir and Walter Eichinger and Matthias Thielmann and Louis Labrousse and Rein, {Kjell Arne} and Jean-Philippe Verhoye and Gino Gerosa and Vinayak Bapat and Hardy Baumbach and Helen Sims and Cornelia Deutsch and Peter Bramlage and Jana Kurucova and Martin Thoenes and Derk Frank",

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T1 - Outcomes after transaortic transcatheter aortic valve implantation: long-term findings from the European ROUTE†

AU - Cocchieri, Riccardo

AU - Petzina, Rainer

AU - Romano, Mauro

AU - Jagielak, Dariusz

AU - Bonaros, Nikolaos

AU - Aiello, Marco

AU - Lapeze, Joel

AU - Laine, Mika

AU - Chocron, Sidney

AU - Muir, Douglas

AU - Eichinger, Walter

AU - Thielmann, Matthias

AU - Labrousse, Louis

AU - Rein, Kjell Arne

AU - Verhoye, Jean-Philippe

AU - Gerosa, Gino

AU - Bapat, Vinayak

AU - Baumbach, Hardy

AU - Sims, Helen

AU - Deutsch, Cornelia

AU - Bramlage, Peter

AU - Kurucova, Jana

AU - Thoenes, Martin

AU - Frank, Derk

PY - 2019/4/1

Y1 - 2019/4/1

N2 - OBJECTIVES: There is lack of data regarding the longer-term outcomes of patients undergoing transaortic (TAo) transcatheter aortic valve implantation (TAVI). We aimed to provide a contemporary snapshot of the types and frequencies of events in the year following TAo-TAVI. METHODS: The Registry of the Utilization of the TAo-TAVI approach using the Edwards SAPIEN Valve (ROUTE) is a multicentre, European, prospective, observational registry of aortic stenosis patients undergoing TAo-TAVI. Patients were grouped according to the composite end point death, myocardial infarction, stroke/transient ischaemic attack, major vascular complications, life-threatening bleeding, acute kidney injury (AKI) and/or cardiovascular rehospitalization. RESULTS: Two hundred and fifty-three patients with a mean age of 81.5 ± 5.8 years were included, of whom 89 (35.2%) patients met the composite end point (the event group) and 164 (64.8%) patients did not (the event-free group). New York Heart Association (NYHA) class III/IV (85.2% vs 71.8%, P = 0.017), Canadian Cardiovascular Society angina class III/IV (22.6% vs 11.4%; P = 0.021), pulmonary disease (32.6% vs 18.9%; P = 0.015) and renal insufficiency (15.7% vs 3.0%; P

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KW - Follow-up

KW - Mortality

KW - Transaortic

KW - Transcatheter aortic valve implantation

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DO - 10.1093/ejcts/ezy333

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EP - 743

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

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ER -