Outcomes in first relapsed-refractory younger patients with mantle cell lymphoma: results from the MANTLE-FIRST study

Carlo Visco, Alice Di Rocco, Andrea Evangelista, Francesca Maria Quaglia, Maria Chiara Tisi, Lucia Morello, Vittorio Ruggero Zilioli, Chiara Rusconi, Stefan Hohaus, Roberta Sciarra, Alessandro Re, Cristina Tecchio, Annalisa Chiappella, Ana Marin-Niebla, Rory McCulloch, Guido Gini, Tommasina Perrone, Luca Nassi, Elsa Pennese, Piero Maria StefaniMaria Christina Cox, Valentina Bozzoli, Alberto Fabbri, Valentina Polli, Simone Ferrero, Maria Isabel Alvarez De Celis, Antonello Sica, Luca Petrucci, Luca Arcaini, Simon Rule, Mauro Krampera, Umberto Vitolo, Monica Balzarotti

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Patients with mantle cell lymphoma (MCL) that fail induction treatment represent a difficult-to-treat population, where no standard therapy exists. We evaluated outcomes in patients with first relapsed-refractory (r/r) MCL after upfront high dose cytarabine including standard regimens. Overall survival (OS-2) and progression-free survival (PFS-2) were estimated from the time of salvage therapy. The previously described threshold of 24 months was used to define patients as early- or late-progressors (POD). Overall, 261 r/r MCL patients were included. Second-line regimens consisted of rituximab-bendamustine (R-B, 21%), R-B and cytarabine (R-BAC, 29%), ibrutinib (19%), and others (31%). The four groups were balanced in terms of clinicopathological features. Adjusting for age and early/late-POD, patients treated with R-BAC had significantly higher complete remission (63%) than comparators. Overall, Ibrutinib and R-BAC were associated with improved median PFS-2 [24 and 25 months, respectively], compared to R-B (13) or others (7). In patients with early-POD (n = 127), ibrutinib was associated with inferior risk of death than comparators (HR 2.41 for R-B, 2.17 for others, 2.78 for R-BAC). In patients with late-POD (n = 134), no significant differences were observed between ibrutinib and bendamustine-based treatments. Ibrutinib was associated with improved outcome in early-POD patients.

Original languageEnglish
Publication statusE-pub ahead of print - Aug 11 2020


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