Outcomes of an automated procedure for the selection of effective platelets for patients refractory to random donors based on cross-matching locally available platelet products

Paolo Rebulla, Fernanda Morelati, Nicoletta Revelli, Maria Antonietta Villa, Cinzia Paccapelo, Angela Nocco, Noemi Greppi, Maurizio Marconi, Agostino Cortelezzi, Nicola Fracchiolla, Giovanni Martinelli, Giorgio Lambertenghi Deliliers

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In 1999, we implemented an automated platelet cross-matching (XM) programme to select compatible platelets from the local inventory for patients refractory to random donor platelets. In this study, we evaluated platelet count increments in 40 consecutive refractory patients (8.3% of 480 consecutive platelet recipients) given 569 cross-match-negative platelets between April 1999 and December 2001. XM was performed automatically with a commercially available immunoadherence assay. Pre-, 1- and 24-h post-transfusion platelet counts (mean ± SD) for the 569 XM-negative platelet transfusions containing 302 ± 71 × 10 9 platelets were 7.7 ± 5.5, 32.0 ± 21.0 and 16.8 ± 15.5 × 10 9/l respectively. Increments were significantly higher (P <0.05, t-test) than those observed in the same patients given 303 random platelet pools (dose = 318 ± 52 × 10 9 platelets) during the month before refractoriness was detected, when pre-, 1- and 24-h post-transfusion counts were 7.0 ± 8.6, 15.9 ± 16.1 and 9.6 ± 12.8 × 10 9/1 respectively. The cost of the platelet XM disposable kit per transfusion to produce 1-h post-transfusion platelet count increments >10 × 10 9/l was euro 447. This programme enabled the rapid selection of effective platelets for refractory patients, from the local inventory.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalBritish Journal of Haematology
Volume125
Issue number1
DOIs
Publication statusPublished - Apr 2004

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Blood Platelets
Platelet Count
Equipment and Supplies
Platelet Transfusion
Costs and Cost Analysis

Keywords

  • Blood transfusion
  • Platelet concentrates
  • Refractoriness

ASJC Scopus subject areas

  • Hematology

Cite this

Outcomes of an automated procedure for the selection of effective platelets for patients refractory to random donors based on cross-matching locally available platelet products. / Rebulla, Paolo; Morelati, Fernanda; Revelli, Nicoletta; Villa, Maria Antonietta; Paccapelo, Cinzia; Nocco, Angela; Greppi, Noemi; Marconi, Maurizio; Cortelezzi, Agostino; Fracchiolla, Nicola; Martinelli, Giovanni; Deliliers, Giorgio Lambertenghi.

In: British Journal of Haematology, Vol. 125, No. 1, 04.2004, p. 83-89.

Research output: Contribution to journalArticle

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