Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT

Gwendolyn van Gorkom, Michel van Gelder, Dirk Jan Eikema, Henric Jan Blok, M. T. van Lint, Yener Koc, Fabio Ciceri, Dietrich Beelen, Patrice Chevallier, Dominik Selleslag, Didier Blaise, Roberto Foá, Paolo Corradini, Luca Castagna, Carol Moreno, Carlos Solano, Lutz Peter Müller, Johanna Tischer, Inken Hilgendorf, Michael HallekJörg Bittenbring, Matthias Theobald, Johannes Schetelig, Nicolaus Kröger, on behalf of the CLL subcommittee, Chronic Malignancies Working Party of the EBMT

Research output: Contribution to journalArticle

Abstract

Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). Recently, haploidentical HCT is gaining interest because of better outcomes with post-transplantation cyclophosphamide (PTCY). We analyzed patients with CLL who received an allogeneic HCT with a haploidentical donor and whose data were available in the EBMT registry. In total 117 patients (74% males) were included; 38% received PTCY as GVHD prophylaxis. For the whole study cohort OS at 2 and 5 yrs was 48 and 38%, respectively. PFS at 2 and 5 yrs was 38 and 31%, respectively. Cumulative incidence (CI) of NRM in the whole group at 2 and 5 years were 40 and 44%, respectively. CI of relapse at 2 and 5 yrs were 22 and 26%, respectively. All outcomes were not statistically different in patients who received PTCY compared to other types of GVHD prophylaxis. In conclusion, results of haploidentical HCT in CLL seem almost identical to those with HLA-matched donors. Thereby, haploidentical HCT is an appropriate alternative in high risk CLL patients with a transplant indication but no available HLA-matched donor. Despite the use of PTCY, the CI of relapse seems not higher than observed after HLA-matched HCT.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBone Marrow Transplantation
DOIs
Publication statusAccepted/In press - Dec 18 2017

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

van Gorkom, G., van Gelder, M., Eikema, D. J., Blok, H. J., van Lint, M. T., Koc, Y., Ciceri, F., Beelen, D., Chevallier, P., Selleslag, D., Blaise, D., Foá, R., Corradini, P., Castagna, L., Moreno, C., Solano, C., Müller, L. P., Tischer, J., Hilgendorf, I., ... Chronic Malignancies Working Party of the EBMT (Accepted/In press). Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT. Bone Marrow Transplantation, 1-9. https://doi.org/10.1038/s41409-017-0023-2