Outcomes of metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated within the BERNIE study: a randomised, phase II study evaluating the addition of bevacizumab to chemotherapy

Andrea Ferrari, Johannes H.M. Merks, Julia C. Chisholm, Daniel Orbach, Bernadette Brennan, Soledad Gallego, Max M. van Noesel, Kieran McHugh, Rick R. van Rijn, Mark N. Gaze, Helene Martelli, Christophe Bergeron, Nadege Corradini, Veronique Minard-Colin, Gianni Bisogno, Birgit Geoerger, Hubert N. Caron, Gian Luca De Salvo, Michela Casanova

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We analysed the cohort of paediatric patients with metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated in the BERNIE protocol, i.e. open-label, multicentre, randomised phase II study evaluating the role of bevacizumab (BO20924/ITCC-006; ClinicalTrials.gov: NCT00643565). Methods: Eligible patients were randomised 1:1 to add or not add bevacizumab to nine courses of intensive multi-drug chemotherapy, followed by 12-month maintenance chemotherapy (plus surgery and radiotherapy). The primary end-point was event-free survival (EFS); secondary objectives were objective response rate (ORR) and overall survival (OS). Results: From 2008 and 2013, 49 NRSTS patients (out of 154 cases) were treated, 26 in the standard arm and 23 in the bevacizumab arm. ORR was seen in 10 out of 36 evaluable cases (27.7%), i.e. 4/18 standard arm cases and 6/18 bevacizumab arm cases. Two-year EFS was 27.3% (95% confidence interval [CI] 13.9–42.5) for all NRSTS patients, i.e. 34.9% (95% CI 14.6–56.2) for bevacizumab arm and 22.9% (95% CI 7.1–43.9) for standard arm (p-value = 0.19). Three-year OS (median follow-up 48.6 months) was 35.2%, with no differences in the two arms. Time to event and time to death were 16.3 and 17.2 months for bevacizumab arm and 2.1 and 7.6 months for standard arm, respectively. Patients not receiving any local treatment on primary disease had a worse outcome as compared to others. Treatment results were better for patients receiving surgical resection and worse for those who did not receive any specific treatment. Conclusion: The addition of the anti-angiogenic agent to the standard chemotherapy did not show statistically significant improvement in survival in metastatic NRSTS.

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalEuropean Journal of Cancer
Volume130
DOIs
Publication statusPublished - May 2020

Keywords

  • Bevacizumab
  • Metastic disease
  • Non-rhabdomyosarcoma soft tissue sarcomas
  • Outcome
  • Paediatric sarcomas
  • Prognostic factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Outcomes of metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated within the BERNIE study: a randomised, phase II study evaluating the addition of bevacizumab to chemotherapy'. Together they form a unique fingerprint.

Cite this