Outer retinal tubulations response to anti-VEGF treatment

Mark Espina, Cheryl A. Arcinue, Feiyan Ma, Natalia Camacho, Giulio Barteselli, Nadia Mendoza, Napoleone Ferrara, William R. Freeman

Research output: Contribution to journalArticle

Abstract

Aim: To review the longitudinal changes of outer retinal tubulations (ORTs) in wet age-related macular degeneration (AMD) and their response to anti-vascular endothelial growth factor (VEGF) therapy by spectraldomain optical coherence tomography (SD-OCT), and to correlate these observations with disease activity, presence or absence of fluid, and patients' demographics. Methods: Retrospective study of wet AMD eyes treated with anti-VEGF agents and showing ORTs on SD-OCT, and the patients' fellow eye with wet AMD but without ORTs. Results: Fifty-one wet AMD eyes from 31 patients diagnosed and treated for wet AMD were included in the review and analysis of data; 33 eyes showed ORTs at baseline, while 18 fellow eyes had no ORTs. During a median follow-up treatment period of 11 months, 23 eyes had stable ORTs and 10 eyes had ORT changes. Among the 10 eyes with ORTs changes, ORTs collapsed during anti-VEGF treatment in 5 eyes but then reappeared within 12 months after stopping treatment. In two eyes, ORTs increased in size during anti-VEGF treatment, while in two other eyes ORTs collapsed without any treatment. In a single eye, ORTs collapsed within 10 months of no treatment and did not reappear upon recurrence of fluid. Eyes with ORTs tended to have lower visual acuity than eyes with no ORTs due to greater disruption of the external limiting membrane in the fovea. Conclusions: ORTs documented by SD-OCT may exhibit multiple types of longitudinal changes, such as collapse, recurrence or enlargement, which could be associated with anti-VEGF treatment or spontaneous. Some ORTs may have a vascular component or may be vascular in nature, considering their response to anti-VEGF treatment, while other ORTs are likely composed only of degenerating photoreceptor cells and may collapse independently from anti-VEGF treatments.

Original languageEnglish
Pages (from-to)819-823
Number of pages5
JournalBritish Journal of Ophthalmology
Volume100
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Vascular Endothelial Growth Factor A
Macular Degeneration
Therapeutics
Optical Coherence Tomography
Blood Vessels
Recurrence
Photoreceptor Cells
Visual Acuity
Retrospective Studies
Demography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Espina, M., Arcinue, C. A., Ma, F., Camacho, N., Barteselli, G., Mendoza, N., ... Freeman, W. R. (2016). Outer retinal tubulations response to anti-VEGF treatment. British Journal of Ophthalmology, 100(6), 819-823. https://doi.org/10.1136/bjophthalmol-2015-307141

Outer retinal tubulations response to anti-VEGF treatment. / Espina, Mark; Arcinue, Cheryl A.; Ma, Feiyan; Camacho, Natalia; Barteselli, Giulio; Mendoza, Nadia; Ferrara, Napoleone; Freeman, William R.

In: British Journal of Ophthalmology, Vol. 100, No. 6, 01.06.2016, p. 819-823.

Research output: Contribution to journalArticle

Espina, M, Arcinue, CA, Ma, F, Camacho, N, Barteselli, G, Mendoza, N, Ferrara, N & Freeman, WR 2016, 'Outer retinal tubulations response to anti-VEGF treatment', British Journal of Ophthalmology, vol. 100, no. 6, pp. 819-823. https://doi.org/10.1136/bjophthalmol-2015-307141
Espina M, Arcinue CA, Ma F, Camacho N, Barteselli G, Mendoza N et al. Outer retinal tubulations response to anti-VEGF treatment. British Journal of Ophthalmology. 2016 Jun 1;100(6):819-823. https://doi.org/10.1136/bjophthalmol-2015-307141
Espina, Mark ; Arcinue, Cheryl A. ; Ma, Feiyan ; Camacho, Natalia ; Barteselli, Giulio ; Mendoza, Nadia ; Ferrara, Napoleone ; Freeman, William R. / Outer retinal tubulations response to anti-VEGF treatment. In: British Journal of Ophthalmology. 2016 ; Vol. 100, No. 6. pp. 819-823.
@article{6e6318e23e364a36a915e0e7909ed64b,
title = "Outer retinal tubulations response to anti-VEGF treatment",
abstract = "Aim: To review the longitudinal changes of outer retinal tubulations (ORTs) in wet age-related macular degeneration (AMD) and their response to anti-vascular endothelial growth factor (VEGF) therapy by spectraldomain optical coherence tomography (SD-OCT), and to correlate these observations with disease activity, presence or absence of fluid, and patients' demographics. Methods: Retrospective study of wet AMD eyes treated with anti-VEGF agents and showing ORTs on SD-OCT, and the patients' fellow eye with wet AMD but without ORTs. Results: Fifty-one wet AMD eyes from 31 patients diagnosed and treated for wet AMD were included in the review and analysis of data; 33 eyes showed ORTs at baseline, while 18 fellow eyes had no ORTs. During a median follow-up treatment period of 11 months, 23 eyes had stable ORTs and 10 eyes had ORT changes. Among the 10 eyes with ORTs changes, ORTs collapsed during anti-VEGF treatment in 5 eyes but then reappeared within 12 months after stopping treatment. In two eyes, ORTs increased in size during anti-VEGF treatment, while in two other eyes ORTs collapsed without any treatment. In a single eye, ORTs collapsed within 10 months of no treatment and did not reappear upon recurrence of fluid. Eyes with ORTs tended to have lower visual acuity than eyes with no ORTs due to greater disruption of the external limiting membrane in the fovea. Conclusions: ORTs documented by SD-OCT may exhibit multiple types of longitudinal changes, such as collapse, recurrence or enlargement, which could be associated with anti-VEGF treatment or spontaneous. Some ORTs may have a vascular component or may be vascular in nature, considering their response to anti-VEGF treatment, while other ORTs are likely composed only of degenerating photoreceptor cells and may collapse independently from anti-VEGF treatments.",
author = "Mark Espina and Arcinue, {Cheryl A.} and Feiyan Ma and Natalia Camacho and Giulio Barteselli and Nadia Mendoza and Napoleone Ferrara and Freeman, {William R.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1136/bjophthalmol-2015-307141",
language = "English",
volume = "100",
pages = "819--823",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "6",

}

TY - JOUR

T1 - Outer retinal tubulations response to anti-VEGF treatment

AU - Espina, Mark

AU - Arcinue, Cheryl A.

AU - Ma, Feiyan

AU - Camacho, Natalia

AU - Barteselli, Giulio

AU - Mendoza, Nadia

AU - Ferrara, Napoleone

AU - Freeman, William R.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Aim: To review the longitudinal changes of outer retinal tubulations (ORTs) in wet age-related macular degeneration (AMD) and their response to anti-vascular endothelial growth factor (VEGF) therapy by spectraldomain optical coherence tomography (SD-OCT), and to correlate these observations with disease activity, presence or absence of fluid, and patients' demographics. Methods: Retrospective study of wet AMD eyes treated with anti-VEGF agents and showing ORTs on SD-OCT, and the patients' fellow eye with wet AMD but without ORTs. Results: Fifty-one wet AMD eyes from 31 patients diagnosed and treated for wet AMD were included in the review and analysis of data; 33 eyes showed ORTs at baseline, while 18 fellow eyes had no ORTs. During a median follow-up treatment period of 11 months, 23 eyes had stable ORTs and 10 eyes had ORT changes. Among the 10 eyes with ORTs changes, ORTs collapsed during anti-VEGF treatment in 5 eyes but then reappeared within 12 months after stopping treatment. In two eyes, ORTs increased in size during anti-VEGF treatment, while in two other eyes ORTs collapsed without any treatment. In a single eye, ORTs collapsed within 10 months of no treatment and did not reappear upon recurrence of fluid. Eyes with ORTs tended to have lower visual acuity than eyes with no ORTs due to greater disruption of the external limiting membrane in the fovea. Conclusions: ORTs documented by SD-OCT may exhibit multiple types of longitudinal changes, such as collapse, recurrence or enlargement, which could be associated with anti-VEGF treatment or spontaneous. Some ORTs may have a vascular component or may be vascular in nature, considering their response to anti-VEGF treatment, while other ORTs are likely composed only of degenerating photoreceptor cells and may collapse independently from anti-VEGF treatments.

AB - Aim: To review the longitudinal changes of outer retinal tubulations (ORTs) in wet age-related macular degeneration (AMD) and their response to anti-vascular endothelial growth factor (VEGF) therapy by spectraldomain optical coherence tomography (SD-OCT), and to correlate these observations with disease activity, presence or absence of fluid, and patients' demographics. Methods: Retrospective study of wet AMD eyes treated with anti-VEGF agents and showing ORTs on SD-OCT, and the patients' fellow eye with wet AMD but without ORTs. Results: Fifty-one wet AMD eyes from 31 patients diagnosed and treated for wet AMD were included in the review and analysis of data; 33 eyes showed ORTs at baseline, while 18 fellow eyes had no ORTs. During a median follow-up treatment period of 11 months, 23 eyes had stable ORTs and 10 eyes had ORT changes. Among the 10 eyes with ORTs changes, ORTs collapsed during anti-VEGF treatment in 5 eyes but then reappeared within 12 months after stopping treatment. In two eyes, ORTs increased in size during anti-VEGF treatment, while in two other eyes ORTs collapsed without any treatment. In a single eye, ORTs collapsed within 10 months of no treatment and did not reappear upon recurrence of fluid. Eyes with ORTs tended to have lower visual acuity than eyes with no ORTs due to greater disruption of the external limiting membrane in the fovea. Conclusions: ORTs documented by SD-OCT may exhibit multiple types of longitudinal changes, such as collapse, recurrence or enlargement, which could be associated with anti-VEGF treatment or spontaneous. Some ORTs may have a vascular component or may be vascular in nature, considering their response to anti-VEGF treatment, while other ORTs are likely composed only of degenerating photoreceptor cells and may collapse independently from anti-VEGF treatments.

UR - http://www.scopus.com/inward/record.url?scp=84971493116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971493116&partnerID=8YFLogxK

U2 - 10.1136/bjophthalmol-2015-307141

DO - 10.1136/bjophthalmol-2015-307141

M3 - Article

AN - SCOPUS:84971493116

VL - 100

SP - 819

EP - 823

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 6

ER -