Outpatient parenteral antibiotic therapy in the elderly: an italian observational multicenter study

S. Esposito, S. Leone, S. Noviello, F. Ianniello, M. Russo, G. Foti, M. S. Carpentieri, C. Cellesi, G. Zanelli, A. Cellini, C. Girmenia, De Lalla, A. Maiello, P. Maio, N. Acone, F. Marranconi, S. Sabbatani, M. Pantaleonin, F. Ghinellin, M. L. SoranzoP. Vigano, T. Re, P. Viale, L. Scudeller

Research output: Contribution to journalArticle

Abstract

Bacterial infections are the most frequent cause of hospitalization in elderly patients. In the early eighties, the advantages of Outpatient Parenteral Antibiotic Therapy (OPAT) were identified in the United States, and suitable therapeutic programs were established. In order to understand the different ways of managing OPAT, a National OPAT Registry was set up in 2003 in Italy. This study analyzes data concerning bacterial infections in 176 elderly patients including demographics, therapeutic management, clinical response, and side-effects. Bone and joint infections (48.9%) and skin and soft tissue infections (27.8%) were the most common infections treated with OPAT. Teicoplanin (28.9%) and ceftriaxone (22.1%) were the top two antibiotics chosen. OPAT was mainly performed at a hospital infusion center (52.8%). The clinical success rate was high and side-effects were low (12.6% of cases). Management of bacterial infections in the elderly with an outpatient program is effective and safe.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalJournal of Chemotherapy
Volume21
Issue number2
Publication statusPublished - Apr 2009

Keywords

  • Bacterial infections
  • Lderly
  • Outpatient Parenteral Antibiotic Therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology

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    Esposito, S., Leone, S., Noviello, S., Ianniello, F., Russo, M., Foti, G., Carpentieri, M. S., Cellesi, C., Zanelli, G., Cellini, A., Girmenia, C., Lalla, D., Maiello, A., Maio, P., Acone, N., Marranconi, F., Sabbatani, S., Pantaleonin, M., Ghinellin, F., ... Scudeller, L. (2009). Outpatient parenteral antibiotic therapy in the elderly: an italian observational multicenter study. Journal of Chemotherapy, 21(2), 193-198.