Outside inside signalling in CD40-mediated B cell activation

O. D'Orlando, G. Gri, G. Cattaruzzi, S. Merluzzi, E. Betto, V. Gattei, Carlo Pucillo

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has been shown to play important roles in T cell-mediated B lymphocyte activation. Ligation of B cell CD40 by CD154 expressed on activated T cells stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. The present review will summarize recent literature data on the various CD40 signalling pathways, which involve both the TNF-R associated factors (TRAFs) and additional signalling proteins, and lead to activation of kinases and transcription factors.

Original languageEnglish
Pages (from-to)49-62
Number of pages14
JournalJournal of Biological Regulators and Homeostatic Agents
Volume21
Issue number3-4
Publication statusPublished - 2007

Fingerprint

B-lymphocytes
B-Lymphocytes
tumor necrosis factors
T-lymphocytes
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Immunoglobulin Class Switching
T-Lymphocytes
antigen presentation
receptors
Germinal Center
Tumor Necrosis Factor Receptors
Antigen Presentation
lymphocyte proliferation
Lymphocyte Activation
Ligation
Cell Differentiation
cell proliferation
phosphotransferases (kinases)
Transcription Factors
Phosphotransferases

Keywords

  • B lymphocyte
  • CD40
  • Signal transduction
  • Transcription factors

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

D'Orlando, O., Gri, G., Cattaruzzi, G., Merluzzi, S., Betto, E., Gattei, V., & Pucillo, C. (2007). Outside inside signalling in CD40-mediated B cell activation. Journal of Biological Regulators and Homeostatic Agents, 21(3-4), 49-62.

Outside inside signalling in CD40-mediated B cell activation. / D'Orlando, O.; Gri, G.; Cattaruzzi, G.; Merluzzi, S.; Betto, E.; Gattei, V.; Pucillo, Carlo.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 21, No. 3-4, 2007, p. 49-62.

Research output: Contribution to journalArticle

D'Orlando, O, Gri, G, Cattaruzzi, G, Merluzzi, S, Betto, E, Gattei, V & Pucillo, C 2007, 'Outside inside signalling in CD40-mediated B cell activation', Journal of Biological Regulators and Homeostatic Agents, vol. 21, no. 3-4, pp. 49-62.
D'Orlando O, Gri G, Cattaruzzi G, Merluzzi S, Betto E, Gattei V et al. Outside inside signalling in CD40-mediated B cell activation. Journal of Biological Regulators and Homeostatic Agents. 2007;21(3-4):49-62.
D'Orlando, O. ; Gri, G. ; Cattaruzzi, G. ; Merluzzi, S. ; Betto, E. ; Gattei, V. ; Pucillo, Carlo. / Outside inside signalling in CD40-mediated B cell activation. In: Journal of Biological Regulators and Homeostatic Agents. 2007 ; Vol. 21, No. 3-4. pp. 49-62.
@article{e06270ad65aa447ba7820ab0002e999d,
title = "Outside inside signalling in CD40-mediated B cell activation",
abstract = "CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has been shown to play important roles in T cell-mediated B lymphocyte activation. Ligation of B cell CD40 by CD154 expressed on activated T cells stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. The present review will summarize recent literature data on the various CD40 signalling pathways, which involve both the TNF-R associated factors (TRAFs) and additional signalling proteins, and lead to activation of kinases and transcription factors.",
keywords = "B lymphocyte, CD40, Signal transduction, Transcription factors",
author = "O. D'Orlando and G. Gri and G. Cattaruzzi and S. Merluzzi and E. Betto and V. Gattei and Carlo Pucillo",
year = "2007",
language = "English",
volume = "21",
pages = "49--62",
journal = "Journal of Biological Regulators and Homeostatic Agents",
issn = "0393-974X",
publisher = "Biolife s.a.s.",
number = "3-4",

}

TY - JOUR

T1 - Outside inside signalling in CD40-mediated B cell activation

AU - D'Orlando, O.

AU - Gri, G.

AU - Cattaruzzi, G.

AU - Merluzzi, S.

AU - Betto, E.

AU - Gattei, V.

AU - Pucillo, Carlo

PY - 2007

Y1 - 2007

N2 - CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has been shown to play important roles in T cell-mediated B lymphocyte activation. Ligation of B cell CD40 by CD154 expressed on activated T cells stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. The present review will summarize recent literature data on the various CD40 signalling pathways, which involve both the TNF-R associated factors (TRAFs) and additional signalling proteins, and lead to activation of kinases and transcription factors.

AB - CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has been shown to play important roles in T cell-mediated B lymphocyte activation. Ligation of B cell CD40 by CD154 expressed on activated T cells stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. The present review will summarize recent literature data on the various CD40 signalling pathways, which involve both the TNF-R associated factors (TRAFs) and additional signalling proteins, and lead to activation of kinases and transcription factors.

KW - B lymphocyte

KW - CD40

KW - Signal transduction

KW - Transcription factors

UR - http://www.scopus.com/inward/record.url?scp=42149125598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42149125598&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 49

EP - 62

JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

SN - 0393-974X

IS - 3-4

ER -