Ovarian cancer and oral contraceptives

collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls

V. Beral, R. Doll, C. Hermon, R. Peto, G. Reeves, L. Brinton, A. C. Green, P. Marchbanks, E. Negri, R. Ness, P. Peeters, M. Vessey, E. E. Calle, C. Rodriguez, L. Dal Maso, R. Talamini, D. Cramer, S. E. Hankinson, S. S. Tworoger, A. Chetrit & 100 others G. Hirsh-Yechezkel, F. Lubin, S. Sadetzki, P. Appleby, E. Banks, A. Berrington de Gonzalez, D. Bull, B. Crossley, A. Goodill, I. Green, J. Green, T. Key, R. Collins, C. A. Gonzalez, N. Lee, H. W. Ory, H. B. Peterson, P. A. Wingo, N. Martin, T. Pardthaisong, S. Silpisornkosol, C. Theetranont, B. Boosiri, S. Chutivongse, P. Jimakorn, P. Virutamasen, C. Wongsrichanalai, L. Titus-Ernstoff, B. J. Mosgaard, D. Yeates, J. Chang-Claude, M. A. Rossing, D. Thomas, N. Weiss, S. Franceschi, C. La Vecchia, H. O. Adami, C. Magnusson, T. Riman, E. Weiderpass, A. Wolk, L. A. Brinton, D. M. Freedman, P. Hartge, J. M. Lacey, R. Hoover, L. J. Schouten, P. A. van den Brandt, N. Chantarakul, S. Koetsawang, D. Rachawat, S. Graff-Iversen, R. Selmer, C. J. Bain, D. M. Purdie, V. Siskind, P. M. Webb, S. E. McCann, P. Hannaford, C. Kay, C. W. Binns, A. H. Lee, M. Zhang, P. Nasca, P. F. Coogan, L. Rosenberg, J. Kelsey, R. Paffenbarger, A. Whittemore, K. Katsouyanni, A. Trichopoulou, D. Trichopoulos, A. Tzonou, A. Dabancens, L. Martinez, R. Molina, O. Salas, M. T. Goodman, G. Laurie, M. E. Carney, L. R. Wilkens, A. Bladstrom, H. Olsson, R. B. Ness, J. A. Grisso, M. Morgan, J. E. Wheeler, J. Casagrande, M. C. Pike, R. K. Ross, A. H. Wu, M. Kumle, E. Lund, L. McGowan, X. O. Shu, W. Zheng, T. M M Farley, S. Holck, O. Meirik, H. A. Risch

Research output: Contribution to journalArticle

445 Citations (Scopus)

Abstract

Background: Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods: Individual data for 23 257 women with ovarian cancer (cases) and 87 303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use was estimated, stratifying by study, age, parity, and hysterectomy. Findings: Overall 7308 (31%) cases and 32 717 (37%) controls had ever used oral contraceptives, for average durations among users of 4·4 and 5·0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average of 56 years. The longer that women had used oral contraceptives, the greater the reduction in ovarian cancer risk (p

Original languageEnglish
Pages (from-to)303-314
Number of pages12
JournalLancet
Volume371
Issue number9609
DOIs
Publication statusPublished - Jan 26 2008

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Mouth Neoplasms
Oral Contraceptives
Ovarian Neoplasms
Epidemiologic Studies
Parity
Hysterectomy
Public Health
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Ovarian cancer and oral contraceptives : collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls. / Beral, V.; Doll, R.; Hermon, C.; Peto, R.; Reeves, G.; Brinton, L.; Green, A. C.; Marchbanks, P.; Negri, E.; Ness, R.; Peeters, P.; Vessey, M.; Calle, E. E.; Rodriguez, C.; Dal Maso, L.; Talamini, R.; Cramer, D.; Hankinson, S. E.; Tworoger, S. S.; Chetrit, A.; Hirsh-Yechezkel, G.; Lubin, F.; Sadetzki, S.; Appleby, P.; Banks, E.; de Gonzalez, A. Berrington; Bull, D.; Crossley, B.; Goodill, A.; Green, I.; Green, J.; Key, T.; Collins, R.; Gonzalez, C. A.; Lee, N.; Ory, H. W.; Peterson, H. B.; Wingo, P. A.; Martin, N.; Pardthaisong, T.; Silpisornkosol, S.; Theetranont, C.; Boosiri, B.; Chutivongse, S.; Jimakorn, P.; Virutamasen, P.; Wongsrichanalai, C.; Titus-Ernstoff, L.; Mosgaard, B. J.; Yeates, D.; Chang-Claude, J.; Rossing, M. A.; Thomas, D.; Weiss, N.; Franceschi, S.; La Vecchia, C.; Adami, H. O.; Magnusson, C.; Riman, T.; Weiderpass, E.; Wolk, A.; Brinton, L. A.; Freedman, D. M.; Hartge, P.; Lacey, J. M.; Hoover, R.; Schouten, L. J.; van den Brandt, P. A.; Chantarakul, N.; Koetsawang, S.; Rachawat, D.; Graff-Iversen, S.; Selmer, R.; Bain, C. J.; Purdie, D. M.; Siskind, V.; Webb, P. M.; McCann, S. E.; Hannaford, P.; Kay, C.; Binns, C. W.; Lee, A. H.; Zhang, M.; Nasca, P.; Coogan, P. F.; Rosenberg, L.; Kelsey, J.; Paffenbarger, R.; Whittemore, A.; Katsouyanni, K.; Trichopoulou, A.; Trichopoulos, D.; Tzonou, A.; Dabancens, A.; Martinez, L.; Molina, R.; Salas, O.; Goodman, M. T.; Laurie, G.; Carney, M. E.; Wilkens, L. R.; Bladstrom, A.; Olsson, H.; Ness, R. B.; Grisso, J. A.; Morgan, M.; Wheeler, J. E.; Casagrande, J.; Pike, M. C.; Ross, R. K.; Wu, A. H.; Kumle, M.; Lund, E.; McGowan, L.; Shu, X. O.; Zheng, W.; Farley, T. M M; Holck, S.; Meirik, O.; Risch, H. A.

In: Lancet, Vol. 371, No. 9609, 26.01.2008, p. 303-314.

Research output: Contribution to journalArticle

Beral, V, Doll, R, Hermon, C, Peto, R, Reeves, G, Brinton, L, Green, AC, Marchbanks, P, Negri, E, Ness, R, Peeters, P, Vessey, M, Calle, EE, Rodriguez, C, Dal Maso, L, Talamini, R, Cramer, D, Hankinson, SE, Tworoger, SS, Chetrit, A, Hirsh-Yechezkel, G, Lubin, F, Sadetzki, S, Appleby, P, Banks, E, de Gonzalez, AB, Bull, D, Crossley, B, Goodill, A, Green, I, Green, J, Key, T, Collins, R, Gonzalez, CA, Lee, N, Ory, HW, Peterson, HB, Wingo, PA, Martin, N, Pardthaisong, T, Silpisornkosol, S, Theetranont, C, Boosiri, B, Chutivongse, S, Jimakorn, P, Virutamasen, P, Wongsrichanalai, C, Titus-Ernstoff, L, Mosgaard, BJ, Yeates, D, Chang-Claude, J, Rossing, MA, Thomas, D, Weiss, N, Franceschi, S, La Vecchia, C, Adami, HO, Magnusson, C, Riman, T, Weiderpass, E, Wolk, A, Brinton, LA, Freedman, DM, Hartge, P, Lacey, JM, Hoover, R, Schouten, LJ, van den Brandt, PA, Chantarakul, N, Koetsawang, S, Rachawat, D, Graff-Iversen, S, Selmer, R, Bain, CJ, Purdie, DM, Siskind, V, Webb, PM, McCann, SE, Hannaford, P, Kay, C, Binns, CW, Lee, AH, Zhang, M, Nasca, P, Coogan, PF, Rosenberg, L, Kelsey, J, Paffenbarger, R, Whittemore, A, Katsouyanni, K, Trichopoulou, A, Trichopoulos, D, Tzonou, A, Dabancens, A, Martinez, L, Molina, R, Salas, O, Goodman, MT, Laurie, G, Carney, ME, Wilkens, LR, Bladstrom, A, Olsson, H, Ness, RB, Grisso, JA, Morgan, M, Wheeler, JE, Casagrande, J, Pike, MC, Ross, RK, Wu, AH, Kumle, M, Lund, E, McGowan, L, Shu, XO, Zheng, W, Farley, TMM, Holck, S, Meirik, O & Risch, HA 2008, 'Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls', Lancet, vol. 371, no. 9609, pp. 303-314. https://doi.org/10.1016/S0140-6736(08)60167-1
Beral, V. ; Doll, R. ; Hermon, C. ; Peto, R. ; Reeves, G. ; Brinton, L. ; Green, A. C. ; Marchbanks, P. ; Negri, E. ; Ness, R. ; Peeters, P. ; Vessey, M. ; Calle, E. E. ; Rodriguez, C. ; Dal Maso, L. ; Talamini, R. ; Cramer, D. ; Hankinson, S. E. ; Tworoger, S. S. ; Chetrit, A. ; Hirsh-Yechezkel, G. ; Lubin, F. ; Sadetzki, S. ; Appleby, P. ; Banks, E. ; de Gonzalez, A. Berrington ; Bull, D. ; Crossley, B. ; Goodill, A. ; Green, I. ; Green, J. ; Key, T. ; Collins, R. ; Gonzalez, C. A. ; Lee, N. ; Ory, H. W. ; Peterson, H. B. ; Wingo, P. A. ; Martin, N. ; Pardthaisong, T. ; Silpisornkosol, S. ; Theetranont, C. ; Boosiri, B. ; Chutivongse, S. ; Jimakorn, P. ; Virutamasen, P. ; Wongsrichanalai, C. ; Titus-Ernstoff, L. ; Mosgaard, B. J. ; Yeates, D. ; Chang-Claude, J. ; Rossing, M. A. ; Thomas, D. ; Weiss, N. ; Franceschi, S. ; La Vecchia, C. ; Adami, H. O. ; Magnusson, C. ; Riman, T. ; Weiderpass, E. ; Wolk, A. ; Brinton, L. A. ; Freedman, D. M. ; Hartge, P. ; Lacey, J. M. ; Hoover, R. ; Schouten, L. J. ; van den Brandt, P. A. ; Chantarakul, N. ; Koetsawang, S. ; Rachawat, D. ; Graff-Iversen, S. ; Selmer, R. ; Bain, C. J. ; Purdie, D. M. ; Siskind, V. ; Webb, P. M. ; McCann, S. E. ; Hannaford, P. ; Kay, C. ; Binns, C. W. ; Lee, A. H. ; Zhang, M. ; Nasca, P. ; Coogan, P. F. ; Rosenberg, L. ; Kelsey, J. ; Paffenbarger, R. ; Whittemore, A. ; Katsouyanni, K. ; Trichopoulou, A. ; Trichopoulos, D. ; Tzonou, A. ; Dabancens, A. ; Martinez, L. ; Molina, R. ; Salas, O. ; Goodman, M. T. ; Laurie, G. ; Carney, M. E. ; Wilkens, L. R. ; Bladstrom, A. ; Olsson, H. ; Ness, R. B. ; Grisso, J. A. ; Morgan, M. ; Wheeler, J. E. ; Casagrande, J. ; Pike, M. C. ; Ross, R. K. ; Wu, A. H. ; Kumle, M. ; Lund, E. ; McGowan, L. ; Shu, X. O. ; Zheng, W. ; Farley, T. M M ; Holck, S. ; Meirik, O. ; Risch, H. A. / Ovarian cancer and oral contraceptives : collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls. In: Lancet. 2008 ; Vol. 371, No. 9609. pp. 303-314.
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title = "Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls",
abstract = "Background: Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods: Individual data for 23 257 women with ovarian cancer (cases) and 87 303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use was estimated, stratifying by study, age, parity, and hysterectomy. Findings: Overall 7308 (31{\%}) cases and 32 717 (37{\%}) controls had ever used oral contraceptives, for average durations among users of 4·4 and 5·0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average of 56 years. The longer that women had used oral contraceptives, the greater the reduction in ovarian cancer risk (p",
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language = "English",
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pages = "303--314",
journal = "The Lancet",
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TY - JOUR

T1 - Ovarian cancer and oral contraceptives

T2 - collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls

AU - Beral, V.

AU - Doll, R.

AU - Hermon, C.

AU - Peto, R.

AU - Reeves, G.

AU - Brinton, L.

AU - Green, A. C.

AU - Marchbanks, P.

AU - Negri, E.

AU - Ness, R.

AU - Peeters, P.

AU - Vessey, M.

AU - Calle, E. E.

AU - Rodriguez, C.

AU - Dal Maso, L.

AU - Talamini, R.

AU - Cramer, D.

AU - Hankinson, S. E.

AU - Tworoger, S. S.

AU - Chetrit, A.

AU - Hirsh-Yechezkel, G.

AU - Lubin, F.

AU - Sadetzki, S.

AU - Appleby, P.

AU - Banks, E.

AU - de Gonzalez, A. Berrington

AU - Bull, D.

AU - Crossley, B.

AU - Goodill, A.

AU - Green, I.

AU - Green, J.

AU - Key, T.

AU - Collins, R.

AU - Gonzalez, C. A.

AU - Lee, N.

AU - Ory, H. W.

AU - Peterson, H. B.

AU - Wingo, P. A.

AU - Martin, N.

AU - Pardthaisong, T.

AU - Silpisornkosol, S.

AU - Theetranont, C.

AU - Boosiri, B.

AU - Chutivongse, S.

AU - Jimakorn, P.

AU - Virutamasen, P.

AU - Wongsrichanalai, C.

AU - Titus-Ernstoff, L.

AU - Mosgaard, B. J.

AU - Yeates, D.

AU - Chang-Claude, J.

AU - Rossing, M. A.

AU - Thomas, D.

AU - Weiss, N.

AU - Franceschi, S.

AU - La Vecchia, C.

AU - Adami, H. O.

AU - Magnusson, C.

AU - Riman, T.

AU - Weiderpass, E.

AU - Wolk, A.

AU - Brinton, L. A.

AU - Freedman, D. M.

AU - Hartge, P.

AU - Lacey, J. M.

AU - Hoover, R.

AU - Schouten, L. J.

AU - van den Brandt, P. A.

AU - Chantarakul, N.

AU - Koetsawang, S.

AU - Rachawat, D.

AU - Graff-Iversen, S.

AU - Selmer, R.

AU - Bain, C. J.

AU - Purdie, D. M.

AU - Siskind, V.

AU - Webb, P. M.

AU - McCann, S. E.

AU - Hannaford, P.

AU - Kay, C.

AU - Binns, C. W.

AU - Lee, A. H.

AU - Zhang, M.

AU - Nasca, P.

AU - Coogan, P. F.

AU - Rosenberg, L.

AU - Kelsey, J.

AU - Paffenbarger, R.

AU - Whittemore, A.

AU - Katsouyanni, K.

AU - Trichopoulou, A.

AU - Trichopoulos, D.

AU - Tzonou, A.

AU - Dabancens, A.

AU - Martinez, L.

AU - Molina, R.

AU - Salas, O.

AU - Goodman, M. T.

AU - Laurie, G.

AU - Carney, M. E.

AU - Wilkens, L. R.

AU - Bladstrom, A.

AU - Olsson, H.

AU - Ness, R. B.

AU - Grisso, J. A.

AU - Morgan, M.

AU - Wheeler, J. E.

AU - Casagrande, J.

AU - Pike, M. C.

AU - Ross, R. K.

AU - Wu, A. H.

AU - Kumle, M.

AU - Lund, E.

AU - McGowan, L.

AU - Shu, X. O.

AU - Zheng, W.

AU - Farley, T. M M

AU - Holck, S.

AU - Meirik, O.

AU - Risch, H. A.

PY - 2008/1/26

Y1 - 2008/1/26

N2 - Background: Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods: Individual data for 23 257 women with ovarian cancer (cases) and 87 303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use was estimated, stratifying by study, age, parity, and hysterectomy. Findings: Overall 7308 (31%) cases and 32 717 (37%) controls had ever used oral contraceptives, for average durations among users of 4·4 and 5·0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average of 56 years. The longer that women had used oral contraceptives, the greater the reduction in ovarian cancer risk (p

AB - Background: Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods: Individual data for 23 257 women with ovarian cancer (cases) and 87 303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use was estimated, stratifying by study, age, parity, and hysterectomy. Findings: Overall 7308 (31%) cases and 32 717 (37%) controls had ever used oral contraceptives, for average durations among users of 4·4 and 5·0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average of 56 years. The longer that women had used oral contraceptives, the greater the reduction in ovarian cancer risk (p

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UR - http://www.scopus.com/inward/citedby.url?scp=39749180158&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(08)60167-1

DO - 10.1016/S0140-6736(08)60167-1

M3 - Article

VL - 371

SP - 303

EP - 314

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9609

ER -