Ovarian cancer is among the most lethal malignant diseases in women who have a lifetime probability of around 1.8%of developing the disease and the 5-year survival rate is near 50%. About 60% of the ovarian lesions derive from the ovarian surface epithelium. Recently, proposals of dividing ovarian carcinoma into two broad categories have been considered: type I, which tends to develop slowly and is a low-grade neoplasm; type II which spreads rapidly and has a higher degree of malignancy. Type I and type II tumors are characterized by distinct gene expression patterns. It may be due to the different histological precursors. In particular, type II tumors might derive from fimbrial epithelium. This new insight may provide a molecular platform for the discovery of new ovarian cancer markers. Several studies underline the high sensitivity of a new marker for ovarian carcinoma: HE4. It seems to be really useful when associated with Ca125 as they distinguish a malignant ovarian lesion from a benign one previously identified by transvaginal ultrasonography, especially in the early stages of the disease and in the pre-menopausal period.
|Translated title of the contribution||Ovarian carcinoma: New insight on pathogenesis and diagnostic markers|
|Number of pages||10|
|Journal||Rivista Italiana della Medicina di Laboratorio|
|Publication status||Published - Dec 2011|
ASJC Scopus subject areas
- Biochemistry, medical
- Medical Laboratory Technology