Abstract
This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in shamoperated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.
| Original language | English |
|---|---|
| Pages (from-to) | 10801-10811 |
| Number of pages | 11 |
| Journal | Oncotarget |
| Volume | 6 |
| Issue number | 13 |
| Publication status | Published - 2015 |
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Keywords
- Estrogens
- Female mammals
- Inflammation
- Life span
- Ovariectomy
ASJC Scopus subject areas
- Oncology
Cite this
Ovariectomy shortens the life span of female mice. / Benedusi, Valeria; Martini, Elisa; Kallikourdis, Marinos; Villa, Alessandro; Meda, Clara; Maggi, Adriana.
In: Oncotarget, Vol. 6, No. 13, 2015, p. 10801-10811.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ovariectomy shortens the life span of female mice
AU - Benedusi, Valeria
AU - Martini, Elisa
AU - Kallikourdis, Marinos
AU - Villa, Alessandro
AU - Meda, Clara
AU - Maggi, Adriana
PY - 2015
Y1 - 2015
N2 - This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in shamoperated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.
AB - This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in shamoperated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.
KW - Estrogens
KW - Female mammals
KW - Inflammation
KW - Life span
KW - Ovariectomy
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M3 - Article
AN - SCOPUS:84929645857
VL - 6
SP - 10801
EP - 10811
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 13
ER -