Ovariectomy shortens the life span of female mice

Valeria Benedusi, Elisa Martini, Marinos Kallikourdis, Alessandro Villa, Clara Meda, Adriana Maggi

Research output: Contribution to journalArticlepeer-review

Abstract

This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in shamoperated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.

Original languageEnglish
Pages (from-to)10801-10811
Number of pages11
JournalOncotarget
Volume6
Issue number13
Publication statusPublished - 2015

Keywords

  • Estrogens
  • Female mammals
  • Inflammation
  • Life span
  • Ovariectomy

ASJC Scopus subject areas

  • Oncology

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