Over-expression of hepatocyte growth factor in human Kaposi's sarcoma

Jeanette A M Maier, Massimo Mariotti, Adriana Albini, Paola Comi, Maria Prat, Paolo M. Comoglio, Marco R. Soria

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Kaposi's sarcoma is a highly vascularized multifocal tumor which frequently appears as a complication of HIV infection. It has been suggested that a disorder in the cytokine network may contribute to the development of the disease. We examined the expression of several cytokines in human sporadic Kaposi's-sarcoma specimens, as well as in spindle cells cultured from human lesions, and consistently found high levels of expression of hepatocyte growth factor (HGF). In addition, human lesion derived spindle cells synthesize and secrete biologically active hepatocyte growth factor and express the hepatocyte-growth-factor receptor (c-MET). Moreover, elevated levels of transforming growth factor β1 (TGβ1) mRNA were found in lesions of human sporadic Kaposi's sarcoma and in lesion-derived spindle cells which also over-express urokinase. Since HGF, TGFβ1 and urokinase are all involved in capillary-vessel organization, dysregulation of these interacting agents may play a role in the initiation and/or progression of Kaposi's sarcoma, stimulating the growth of spindle cells and recruiting endothelial cells into the lesion.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalInternational Journal of Cancer
Issue number2
Publication statusPublished - Jan 17 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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