Overall Contribution of Chest Wall Hyperinflation to Breathlessness in Asthma

Mario Filippelli, Roberto Duranti, Francesco Gigliotti, Roberto Bianchi, Michele Grazzini, Loredana Stendardi, Giorgio Scano

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Studies suggest that the increased volume of both abdominal and rib cage compartments of the chest wall contribute to dyspnea during methacholine-induced airway narrowing. Material: Eight male patients with asthma aged 34 ± 13 years (mean ± SD) before and during methacholine challenge. Methods: The volume of the chest wall (Vcw), volume of the abdomen (Vab), and volume of the rib cage (Vrc) were measured by using a three-dimensional optoelectronic plethysmography. Results: During methacholine challenge, the increase in end-expiratory Vcw (Vcw,ee) [0.55 ± 0.23 L, p <0.001] was due to increased Vrc (0.37 ± 0.20 L, p <0.01) and, to a lesser extent, Vab (0.18 ± 0.10 L, p <0.005). Linear univariate regression analysis showed that changes in dyspnea (Borg scale) with the highest methacholine dose correlated with both ΔFEV 1 and ΔVcw,ee. Multiple regression analysis with the Borg score as dependent variable and all other ventilatory indexes as independent variables showed that ΔVcw,ee and ΔFEV 1 were the only significant contributors to the Borg score. Taken together Vcw,ee and FEV 1 explained 56% of variance in the Borg score (r 2 = 0.56), although Vcw,ee explained 48% of it. Conclusions: During methacholine challenge in patients with asthma, the overall increase in Vcw,ee is a better predictor of dyspnea that the reduction in FEV 1.

Original languageEnglish
Pages (from-to)2164-2170
Number of pages7
JournalChest
Volume124
Issue number6
DOIs
Publication statusPublished - Dec 2003

Fingerprint

Thoracic Wall
Dyspnea
Asthma
Methacholine Chloride
Abdomen
Regression Analysis
Plethysmography
Linear Models

Keywords

  • Asthma
  • Chest wall
  • Dyspnea
  • Hyperinflation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Filippelli, M., Duranti, R., Gigliotti, F., Bianchi, R., Grazzini, M., Stendardi, L., & Scano, G. (2003). Overall Contribution of Chest Wall Hyperinflation to Breathlessness in Asthma. Chest, 124(6), 2164-2170. https://doi.org/10.1378/chest.124.6.2164

Overall Contribution of Chest Wall Hyperinflation to Breathlessness in Asthma. / Filippelli, Mario; Duranti, Roberto; Gigliotti, Francesco; Bianchi, Roberto; Grazzini, Michele; Stendardi, Loredana; Scano, Giorgio.

In: Chest, Vol. 124, No. 6, 12.2003, p. 2164-2170.

Research output: Contribution to journalArticle

Filippelli, M, Duranti, R, Gigliotti, F, Bianchi, R, Grazzini, M, Stendardi, L & Scano, G 2003, 'Overall Contribution of Chest Wall Hyperinflation to Breathlessness in Asthma', Chest, vol. 124, no. 6, pp. 2164-2170. https://doi.org/10.1378/chest.124.6.2164
Filippelli M, Duranti R, Gigliotti F, Bianchi R, Grazzini M, Stendardi L et al. Overall Contribution of Chest Wall Hyperinflation to Breathlessness in Asthma. Chest. 2003 Dec;124(6):2164-2170. https://doi.org/10.1378/chest.124.6.2164
Filippelli, Mario ; Duranti, Roberto ; Gigliotti, Francesco ; Bianchi, Roberto ; Grazzini, Michele ; Stendardi, Loredana ; Scano, Giorgio. / Overall Contribution of Chest Wall Hyperinflation to Breathlessness in Asthma. In: Chest. 2003 ; Vol. 124, No. 6. pp. 2164-2170.
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