Overall survival in BRCA-associated ovarian cancer: Case-control study of an Italian series

G. Artioli, L. Borgato, A. Cappetta, J. Wabersich, S. Mocellin, M. Dalla Palma, O. Nicoletto

Research output: Contribution to journalArticle

Abstract

About 10% of all ovarian cancers are due to BRCA 1 and/or BRCA 2 mutations. Some studies have shown that patients belonging to this group have a better survival compared to sporadic groups but data are still inconclusive. The aim of this study was to investigate overall survival in patients with ovarian cancer and germ-line mutations in the BRCA1/2 genes in comparison to highrisk patients, defined as patients with ovarian cancer and a strong family history of breast and ovarian cancer, but who tested negative for the BRCA mutation. We collected all the clinical features and did follow-up. The two groups showed similar characteristics concerning age at diagnosis, histological type and stage. Grade 3 was more frequent in the BRCA group. Survival data did not show any advantage for the BRCA mutated eroup.

Original languageEnglish
Pages (from-to)658-661
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume31
Issue number6
Publication statusPublished - 2010

Keywords

  • BRCA1
  • BRCA2
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Fingerprint Dive into the research topics of 'Overall survival in BRCA-associated ovarian cancer: Case-control study of an Italian series'. Together they form a unique fingerprint.

  • Cite this

    Artioli, G., Borgato, L., Cappetta, A., Wabersich, J., Mocellin, S., Dalla Palma, M., & Nicoletto, O. (2010). Overall survival in BRCA-associated ovarian cancer: Case-control study of an Italian series. European Journal of Gynaecological Oncology, 31(6), 658-661.