Overcoming the challenges now limiting islet transplantation: A sequential, integrated approach

Antonello Pileggi, Lorenzo Cobianchi, Luca Inverardi, Camillo Ricordi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Steady improvements in islet cell processing technology and immunosuppressive protocols have made pancreatic islet transplantation a clinical reality for the treatment of patients with Type 1 diabetes mellitus (T1DM). Recent trials are showing that improved glycemic metabolic control, prevention of severe hypoglycemia, and better quality of life can be reproducibly achieved after transplantation of allogeneic islets in patients with unstable T1DM. Despite these encouraging results, challenges ahead comprise obtaining adequate islet cells for transplant, enhancing islets engraftment, sustaining b cell mass and function over time, and defining effective immune interventions, among others. In order to overcome the current hurdles to the widespread application of islet transplantation there is a need for implementation of integrated, sequential therapeutic approaches.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages383-398
Number of pages16
Volume1079
DOIs
Publication statusPublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1079
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • b cell replacement
  • Bioengineering
  • Cytoprotection
  • Diabetes
  • Immune intervention
  • Immunosuppression
  • Insulin
  • Islet transplantation
  • Pancreas
  • Stem cells
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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