Overexpression of α-synuclein following methamphetamine: Is it good or bad?

Giuseppe Mauceli, Carla I. Busceti, Antonio Pellegrini, Paola Soldani, Paola Lenzi, Antonio Paparelli, Francesco Fornai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

α-Synuclein is a presynaptic protein involved in various degenerative disorders now defined as synucleinopathies. These include neurological diseases that share a few pathological features consisting of aggregates of both normal and altered α-synuclein within specific neuronal populations and/or glial cells. The prototype of synucleinopathies is represented by Parkinson's disease (PD) in which α-synuclein is identified as a constant component of neuronal pale eosinophilic inclusions: "the Lewy Bodies." In the present article, we discuss the potential significance of amphetamine-induced overespression of α-synuclein in light of clinical findings showing neurodegeneration following overespression of α-synuclein and recent experimental studies that measured increased expression of α-synuclein following amphetamine derivatives.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages191-197
Number of pages7
Volume1074
DOIs
Publication statusPublished - Aug 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1074
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • α-synuclein
  • Amphetamine derivatives
  • Dopaminergic neuron
  • Neurotoxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Mauceli, G., Busceti, C. I., Pellegrini, A., Soldani, P., Lenzi, P., Paparelli, A., & Fornai, F. (2006). Overexpression of α-synuclein following methamphetamine: Is it good or bad? In Annals of the New York Academy of Sciences (Vol. 1074, pp. 191-197). (Annals of the New York Academy of Sciences; Vol. 1074). https://doi.org/10.1196/annals.1369.019