Abstract
Background and methods. Philadelphia (Ph) positive chronic myeloid leukemia (CML) cannot be induced into a true remission with conventional chemotherapy. Blast cells and precursors obtained from 51 Ph+ CML cases were assayed for expression of the multidrug resistance (MDR)-associated glycoprotein (p 170) by immunocytochemistty (APAAP) with the MRK-16 monoclonal antibody. Results and conclusions. Positive cells were found in 11/17 cases in chronic phase (65%), in 4/8 cases in accelerated phase, and in 23/26 cases in blastic phase (89%). The proportion of positive cells, which ranged between less than 1% and 95%, was higher in blastic phase (mean 32 ± 29.9) than in chronic phase (mean 3 ± 5.3) (p = 0.006). These findings show that p170 overexpression is common in Ph+ CML, especially after progression to blastic phase, and suggest that p170-related MDB may contribute significantly to treatment failure.
Original language | English |
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Pages (from-to) | 200-204 |
Number of pages | 5 |
Journal | Haematologica |
Volume | 79 |
Issue number | 3 |
Publication status | Published - 1994 |
Keywords
- chemotherapy
- chronic myeloid leukemia
- drug resistance
ASJC Scopus subject areas
- Hematology