Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: An immunohistochemical study on 109 Italian patients

A. D'Errico, W. F. Grigioni, M. Fiorentino, P. Baccarini, G. L. Grazi, A. M. Mancini

Research output: Contribution to journalArticle


The overexpression of p53 protein and the Ki67 proliferative index was evaluated in 96 hepatocellular carcinomas (HCC), 67 in cirrhotic livers and 29 in non-cirrhotic ones, and in 13 non-carcinomatous lesions, all surgically resected from Italian patients. Overexpression of p53 was detected only in carcinomatous lesions, and was significantly related to the grade of HCC (P

Original languageEnglish
Pages (from-to)682-687
Number of pages6
JournalPathology International
Issue number9
Publication statusPublished - 1994



  • Hepatocellular carcinoma
  • Ki67
  • P53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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