Abstract
Loss of expression of the cyclin-dependent kinase inhibitor p27 through enhanced protein degradation frequently occurs in human cancer. Degradation of p27 requires ubiquitination by the S-phase kinase-associated protein 2 (Skp2), a member of the F-box family of Skp1-Cullin-F-box protein ubiquitin ligases. In the present study, we have investigated the role of Skp2 in human thyroid tumours. Immunohistochemistry analysis showed that Skp2 was overexpressed significantly in thyroid carcinomas (26 out of 51) compared with goitres (0 out of 12, P
| Original language | English |
|---|---|
| Pages (from-to) | 405-420 |
| Number of pages | 16 |
| Journal | Endocrine-Related Cancer |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2007 |
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ASJC Scopus subject areas
- Endocrinology
- Oncology
- Cancer Research
- Endocrinology, Diabetes and Metabolism
Cite this
Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer. / Chiappetta, Gennaro; De Marco, Carmela; Quintiero, Alfina; Califano, Daniela; Gherardi, Simona; Malanga, Donatella; Scrima, Marianna; Montero-Conde, Cristina; Cito, Letizia; Monaco, Mario; Motti, Maria Letizia; Pasquinelli, Rosa; Agosti, Valter; Robledo, Mercedes; Fusco, Alfredo; Viglietto, Giuseppe.
In: Endocrine-Related Cancer, Vol. 14, No. 2, 06.2007, p. 405-420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer
AU - Chiappetta, Gennaro
AU - De Marco, Carmela
AU - Quintiero, Alfina
AU - Califano, Daniela
AU - Gherardi, Simona
AU - Malanga, Donatella
AU - Scrima, Marianna
AU - Montero-Conde, Cristina
AU - Cito, Letizia
AU - Monaco, Mario
AU - Motti, Maria Letizia
AU - Pasquinelli, Rosa
AU - Agosti, Valter
AU - Robledo, Mercedes
AU - Fusco, Alfredo
AU - Viglietto, Giuseppe
PY - 2007/6
Y1 - 2007/6
N2 - Loss of expression of the cyclin-dependent kinase inhibitor p27 through enhanced protein degradation frequently occurs in human cancer. Degradation of p27 requires ubiquitination by the S-phase kinase-associated protein 2 (Skp2), a member of the F-box family of Skp1-Cullin-F-box protein ubiquitin ligases. In the present study, we have investigated the role of Skp2 in human thyroid tumours. Immunohistochemistry analysis showed that Skp2 was overexpressed significantly in thyroid carcinomas (26 out of 51) compared with goitres (0 out of 12, P
AB - Loss of expression of the cyclin-dependent kinase inhibitor p27 through enhanced protein degradation frequently occurs in human cancer. Degradation of p27 requires ubiquitination by the S-phase kinase-associated protein 2 (Skp2), a member of the F-box family of Skp1-Cullin-F-box protein ubiquitin ligases. In the present study, we have investigated the role of Skp2 in human thyroid tumours. Immunohistochemistry analysis showed that Skp2 was overexpressed significantly in thyroid carcinomas (26 out of 51) compared with goitres (0 out of 12, P
UR - http://www.scopus.com/inward/record.url?scp=34547820267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547820267&partnerID=8YFLogxK
U2 - 10.1677/ERC-06-0030
DO - 10.1677/ERC-06-0030
M3 - Article
C2 - 17639054
AN - SCOPUS:34547820267
VL - 14
SP - 405
EP - 420
JO - Endocrine-Related Cancer
JF - Endocrine-Related Cancer
SN - 1351-0088
IS - 2
ER -