Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer

Gennaro Chiappetta, Carmela De Marco, Alfina Quintiero, Daniela Califano, Simona Gherardi, Donatella Malanga, Marianna Scrima, Cristina Montero-Conde, Letizia Cito, Mario Monaco, Maria Letizia Motti, Rosa Pasquinelli, Valter Agosti, Mercedes Robledo, Alfredo Fusco, Giuseppe Viglietto

Research output: Contribution to journalArticle

Abstract

Loss of expression of the cyclin-dependent kinase inhibitor p27 through enhanced protein degradation frequently occurs in human cancer. Degradation of p27 requires ubiquitination by the S-phase kinase-associated protein 2 (Skp2), a member of the F-box family of Skp1-Cullin-F-box protein ubiquitin ligases. In the present study, we have investigated the role of Skp2 in human thyroid tumours. Immunohistochemistry analysis showed that Skp2 was overexpressed significantly in thyroid carcinomas (26 out of 51) compared with goitres (0 out of 12, P

Original languageEnglish
Pages (from-to)405-420
Number of pages16
JournalEndocrine-Related Cancer
Volume14
Issue number2
DOIs
Publication statusPublished - Jun 2007

Fingerprint

S-Phase Kinase-Associated Proteins
Thyroid Neoplasms
SKP Cullin F-Box Protein Ligases
Cyclin-Dependent Kinase Inhibitor p27
Ubiquitination
Goiter
Ligases
Ubiquitin
Proteolysis
Neoplasms
Thyroid Gland
Immunohistochemistry

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

Chiappetta, G., De Marco, C., Quintiero, A., Califano, D., Gherardi, S., Malanga, D., ... Viglietto, G. (2007). Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer. Endocrine-Related Cancer, 14(2), 405-420. https://doi.org/10.1677/ERC-06-0030

Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer. / Chiappetta, Gennaro; De Marco, Carmela; Quintiero, Alfina; Califano, Daniela; Gherardi, Simona; Malanga, Donatella; Scrima, Marianna; Montero-Conde, Cristina; Cito, Letizia; Monaco, Mario; Motti, Maria Letizia; Pasquinelli, Rosa; Agosti, Valter; Robledo, Mercedes; Fusco, Alfredo; Viglietto, Giuseppe.

In: Endocrine-Related Cancer, Vol. 14, No. 2, 06.2007, p. 405-420.

Research output: Contribution to journalArticle

Chiappetta, G, De Marco, C, Quintiero, A, Califano, D, Gherardi, S, Malanga, D, Scrima, M, Montero-Conde, C, Cito, L, Monaco, M, Motti, ML, Pasquinelli, R, Agosti, V, Robledo, M, Fusco, A & Viglietto, G 2007, 'Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer', Endocrine-Related Cancer, vol. 14, no. 2, pp. 405-420. https://doi.org/10.1677/ERC-06-0030
Chiappetta, Gennaro ; De Marco, Carmela ; Quintiero, Alfina ; Califano, Daniela ; Gherardi, Simona ; Malanga, Donatella ; Scrima, Marianna ; Montero-Conde, Cristina ; Cito, Letizia ; Monaco, Mario ; Motti, Maria Letizia ; Pasquinelli, Rosa ; Agosti, Valter ; Robledo, Mercedes ; Fusco, Alfredo ; Viglietto, Giuseppe. / Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer. In: Endocrine-Related Cancer. 2007 ; Vol. 14, No. 2. pp. 405-420.
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