Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer

Gennaro Chiappetta, Carmela De Marco, Alfina Quintiero, Daniela Califano, Simona Gherardi, Donatella Malanga, Marianna Scrima, Cristina Montero-Conde, Letizia Cito, Mario Monaco, Maria Letizia Motti, Rosa Pasquinelli, Valter Agosti, Mercedes Robledo, Alfredo Fusco, Giuseppe Viglietto

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of expression of the cyclin-dependent kinase inhibitor p27 through enhanced protein degradation frequently occurs in human cancer. Degradation of p27 requires ubiquitination by the S-phase kinase-associated protein 2 (Skp2), a member of the F-box family of Skp1-Cullin-F-box protein ubiquitin ligases. In the present study, we have investigated the role of Skp2 in human thyroid tumours. Immunohistochemistry analysis showed that Skp2 was overexpressed significantly in thyroid carcinomas (26 out of 51) compared with goitres (0 out of 12, P

Original languageEnglish
Pages (from-to)405-420
Number of pages16
JournalEndocrine-Related Cancer
Volume14
Issue number2
DOIs
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

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