Overground robot assisted gait trainer for the treatment of drug-resistant freezing of gait in Parkinson disease

Manuela Pilleri, Luca Weis, Letizia Zabeo, Konstantinos Koutsikos, Roberta Biundo, Silvia Facchini, Simonetta Rossi, Stefano Masiero, Angelo Antonini

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Freezing of Gait (FOG) is a frequent and disabling feature of Parkinson disease (PD). Gait rehabilitation assisted by electromechanical devices, such as training on treadmill associated with sensory cues or assisted by gait orthosis have been shown to improve FOG. Overground robot assisted gait training (RGT) has been recently tested in patients with PD with improvement of several gait parameters. We here evaluated the effectiveness of RGT on FOG severity and gait abnormalities in PD patients. Eighteen patients with FOG resistant to dopaminergic medications were treated with 15 sessions of RGT and underwent an extensive clinical evaluation before and after treatment. The main outcome measures were FOG questionnaire (FOGQ) global score and specific tasks for gait assessment, namely 10 meter walking test (10 MWT), Timed Up and Go test (TUG) and 360° narrow turns (360 NT). Balance was also evaluated through Fear of Falling Efficacy Scale (FFES), assessing self perceived stability and Berg Balance Scale (BBS), for objective examination. After treatment, FOGQ score was significantly reduced (P = 0.023). We also found a significant reduction of time needed to complete TUG, 10 MWT, and 360 NT (P = 0.009, 0.004 and 0.04, respectively). By contrast the number of steps and the number of freezing episodes recorded at each gait task did not change. FFES and BBS scores also improved, with positive repercussions on performance on daily activity and quality of life. Our results indicate that RGT is a useful strategy for the treatment of drug refractory FOG.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalJournal of the Neurological Sciences
Volume355
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2015

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Gait
Freezing
Parkinson Disease
Pharmaceutical Preparations
Therapeutics
Accidental Falls
Walking
Fear
Orthotic Devices
Cues

Keywords

  • Balance
  • Freezing of gait
  • Gait
  • Parkinson disease
  • Rehabilitation
  • Robot assisted gait trainer

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Overground robot assisted gait trainer for the treatment of drug-resistant freezing of gait in Parkinson disease. / Pilleri, Manuela; Weis, Luca; Zabeo, Letizia; Koutsikos, Konstantinos; Biundo, Roberta; Facchini, Silvia; Rossi, Simonetta; Masiero, Stefano; Antonini, Angelo.

In: Journal of the Neurological Sciences, Vol. 355, No. 1-2, 15.08.2015, p. 75-78.

Research output: Contribution to journalArticle

Pilleri, M, Weis, L, Zabeo, L, Koutsikos, K, Biundo, R, Facchini, S, Rossi, S, Masiero, S & Antonini, A 2015, 'Overground robot assisted gait trainer for the treatment of drug-resistant freezing of gait in Parkinson disease', Journal of the Neurological Sciences, vol. 355, no. 1-2, pp. 75-78. https://doi.org/10.1016/j.jns.2015.05.023
Pilleri, Manuela ; Weis, Luca ; Zabeo, Letizia ; Koutsikos, Konstantinos ; Biundo, Roberta ; Facchini, Silvia ; Rossi, Simonetta ; Masiero, Stefano ; Antonini, Angelo. / Overground robot assisted gait trainer for the treatment of drug-resistant freezing of gait in Parkinson disease. In: Journal of the Neurological Sciences. 2015 ; Vol. 355, No. 1-2. pp. 75-78.
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