Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

Francesca Colavita, Serena Vita, Eleonora Lalle, Fabrizio Carletti, Licia Bordi, Donatella Vincenti, Irene Pozzetto, Massimo Aiuti, Francesco Vairo, Maria Rosaria Capobianchi, Miriam Lichtner, Concetta Castilletti

Research output: Contribution to journalArticlepeer-review

Abstract

Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.

Original languageEnglish
Pages (from-to)ofy276
JournalOpen Forum Infectious Diseases
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 2018

Fingerprint

Dive into the research topics of 'Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak'. Together they form a unique fingerprint.

Cite this