Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

Francesca Colavita; Serena Vita; Eleonora Lalle; Fabrizio Carletti; Licia Bordi; Donatella Vincenti; Irene Pozzetto; Massimo Aiuti; Francesco Vairo; Maria Rosaria Capobianchi; Miriam Lichtner; Concetta Castilletti

doi:10.1093/ofid/ofy276

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

Francesca Colavita, Serena Vita, Eleonora Lalle, Fabrizio Carletti, Licia Bordi, Donatella Vincenti, Irene Pozzetto, Massimo Aiuti, Francesco Vairo, Maria Rosaria Capobianchi, Miriam Lichtner, Concetta Castilletti

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article

Abstract

Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.

Original language	English
Pages (from-to)	ofy276
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	11
DOIs	https://doi.org/10.1093/ofid/ofy276
Publication status	Published - Nov 2018

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Colavita, F., Vita, S., Lalle, E., Carletti, F., Bordi, L., Vincenti, D., Pozzetto, I., Aiuti, M., Vairo, F., Capobianchi, M. R., Lichtner, M., & Castilletti, C. (2018). Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. Open Forum Infectious Diseases, 5(11), ofy276. https://doi.org/10.1093/ofid/ofy276

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. / Colavita, Francesca; Vita, Serena; Lalle, Eleonora ; Carletti, Fabrizio ; Bordi, Licia ; Vincenti, Donatella; Pozzetto, Irene; Aiuti, Massimo; Vairo, Francesco ; Capobianchi, Maria Rosaria; Lichtner, Miriam; Castilletti, Concetta.

In: Open Forum Infectious Diseases, Vol. 5, No. 11, 11.2018, p. ofy276.

Research output: Contribution to journal › Article

Colavita, F, Vita, S, Lalle, E , Carletti, F , Bordi, L , Vincenti, D, Pozzetto, I, Aiuti, M, Vairo, F , Capobianchi, MR, Lichtner, M & Castilletti, C 2018, 'Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak', Open Forum Infectious Diseases, vol. 5, no. 11, pp. ofy276. https://doi.org/10.1093/ofid/ofy276

Colavita, Francesca ; Vita, Serena ; Lalle, Eleonora ; Carletti, Fabrizio ; Bordi, Licia ; Vincenti, Donatella ; Pozzetto, Irene ; Aiuti, Massimo ; Vairo, Francesco ; Capobianchi, Maria Rosaria ; Lichtner, Miriam ; Castilletti, Concetta. / Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. In: Open Forum Infectious Diseases. 2018 ; Vol. 5, No. 11. pp. ofy276.

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10.1093/ofid/ofy276