Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

Francesca Colavita; Serena Vita; Eleonora Lalle; Fabrizio Carletti; Licia Bordi; Donatella Vincenti; Irene Pozzetto; Massimo Aiuti; Francesco Vairo; Maria Rosaria Capobianchi; Miriam Lichtner; Concetta Castilletti

doi:10.1093/ofid/ofy276

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

Francesca Colavita, Serena Vita, Eleonora Lalle, Fabrizio Carletti, Licia Bordi, Donatella Vincenti, Irene Pozzetto, Massimo Aiuti, Francesco Vairo, Maria Rosaria Capobianchi, Miriam Lichtner, Concetta Castilletti

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.

Original language	English
Pages (from-to)	ofy276
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	11
DOIs	https://doi.org/10.1093/ofid/ofy276
Publication status	Published - Nov 2018

Access to Document

10.1093/ofid/ofy276

Fingerprint Dive into the research topics of 'Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak'. Together they form a unique fingerprint.

Cite this

Colavita, F., Vita, S., Lalle, E., Carletti, F., Bordi, L., Vincenti, D., Pozzetto, I., Aiuti, M., Vairo, F., Capobianchi, M. R., Lichtner, M., & Castilletti, C. (2018). Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. Open Forum Infectious Diseases, 5(11), ofy276. https://doi.org/10.1093/ofid/ofy276

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. / Colavita, Francesca; Vita, Serena; Lalle, Eleonora ; Carletti, Fabrizio ; Bordi, Licia ; Vincenti, Donatella; Pozzetto, Irene; Aiuti, Massimo; Vairo, Francesco ; Capobianchi, Maria Rosaria; Lichtner, Miriam; Castilletti, Concetta.

In: Open Forum Infectious Diseases, Vol. 5, No. 11, 11.2018, p. ofy276.

Research output: Contribution to journal › Article › peer-review

Colavita, F, Vita, S, Lalle, E , Carletti, F , Bordi, L , Vincenti, D, Pozzetto, I, Aiuti, M, Vairo, F , Capobianchi, MR, Lichtner, M & Castilletti, C 2018, 'Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak', Open Forum Infectious Diseases, vol. 5, no. 11, pp. ofy276. https://doi.org/10.1093/ofid/ofy276

Colavita, Francesca ; Vita, Serena ; Lalle, Eleonora ; Carletti, Fabrizio ; Bordi, Licia ; Vincenti, Donatella ; Pozzetto, Irene ; Aiuti, Massimo ; Vairo, Francesco ; Capobianchi, Maria Rosaria ; Lichtner, Miriam ; Castilletti, Concetta. / Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. In: Open Forum Infectious Diseases. 2018 ; Vol. 5, No. 11. pp. ofy276.

@article{b1528464f50d4a84bd427cf3716a6154,

title = "Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak",

abstract = "Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.",

author = "Francesca Colavita and Serena Vita and Eleonora Lalle and Fabrizio Carletti and Licia Bordi and Donatella Vincenti and Irene Pozzetto and Massimo Aiuti and Francesco Vairo and Capobianchi, {Maria Rosaria} and Miriam Lichtner and Concetta Castilletti",

year = "2018",

month = nov,

doi = "10.1093/ofid/ofy276",

language = "English",

volume = "5",

pages = "ofy276",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "11",

}

TY - JOUR

T1 - Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

AU - Colavita, Francesca

AU - Vita, Serena

AU - Lalle, Eleonora

AU - Carletti, Fabrizio

AU - Bordi, Licia

AU - Vincenti, Donatella

AU - Pozzetto, Irene

AU - Aiuti, Massimo

AU - Vairo, Francesco

AU - Capobianchi, Maria Rosaria

AU - Lichtner, Miriam

AU - Castilletti, Concetta

PY - 2018/11

Y1 - 2018/11

N2 - Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.

AB - Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.

U2 - 10.1093/ofid/ofy276

DO - 10.1093/ofid/ofy276

M3 - Article

C2 - 30539034

VL - 5

SP - ofy276

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

SN - 2328-8957

IS - 11

ER -