Oversecretion of cytokines and chemokines in lupus nephritis is regulated by intraparenchymal dendritic cells: A review

Marco Tucci, Sabino Ciavarella, Sabino Strippoli, Franco Dammacco, Franco Silvestris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lupus nephritis (LN) occurs in more than one-third of patients with systemic lupus erythematosus. Its pathogenesis is attributed to the glomerular deposition of immune complexes as well as to imbalance of the cytokine homeostasis. In this context, high production of cytokines and chemokines by dendritic cells (DCs) may concur to LN. In addition, urinary cytokine excretion may reflect the accumulation of DCs within glomeruli. DCs are differentiated in both myeloid and plasmacytoid (p) subsets in relation to their typical antigen and chemokine expression. Both subsets migrate in response to chemotactic stimuli because pDCs are susceptible to IL-18 expressed by resident glomerular cells. pDCs bear the IL-18R, and it is conceivable that DCs migrate to the kidney under the attraction of IL-18. Therefore, the depletion of DCs reflects the inflammation severity in LN, whereas measurement of Th1 cytokines may represent an effective tool for monitoring the onset of LN.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages449-457
Number of pages9
Volume1173
DOIs
Publication statusPublished - Sep 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1173
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Chemokines
  • Cytokines
  • Dendritic cells
  • Lupus nephritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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