Overview in the clinical management of patients with seronegative villous atrophy

Annalisa Schiepatti, David S. Sanders, Martina Zuffada, Ombretta Luinetti, Adam Iraqi, Federico Biagi

Research output: Contribution to journalArticle

Abstract

Differential diagnosis and management of enteropathies found in the context of seronegative villous atrophy (VA) are still a clinical challenge. Although seronegative coeliac disease may be the most frequent cause of serology-negative VA, other conditions must be taken into account in the differential diagnosis of seronegative VA. The rarity of these enteropathies with frequent overlapping of histological features may result in misclassification of such patients as affected by a seronegative or a refractory form of coeliac disease with consequent inappropriate treatments and long-term morbidity. The aim of this review is to summarize the current knowledge and to provide an evidence base and practical algorithmic approach for the investigation and management of seronegative VA.
Original languageEnglish
JournalEuropean journal of gastroenterology & hepatology
Volume31
Issue number4
Publication statusPublished - 2019

Fingerprint

Atrophy
Celiac Disease
Differential Diagnosis
Serology
Morbidity
Therapeutics

Keywords

  • differential diagnosis
  • seronegative coeliac disease
  • villous atrophy

Cite this

Overview in the clinical management of patients with seronegative villous atrophy. / Schiepatti, Annalisa; Sanders, David S.; Zuffada, Martina; Luinetti, Ombretta; Iraqi, Adam; Biagi, Federico.

In: European journal of gastroenterology & hepatology, Vol. 31, No. 4, 2019.

Research output: Contribution to journalArticle

@article{badc53e7bb5e4e8ca46449b657defb25,
title = "Overview in the clinical management of patients with seronegative villous atrophy",
abstract = "Differential diagnosis and management of enteropathies found in the context of seronegative villous atrophy (VA) are still a clinical challenge. Although seronegative coeliac disease may be the most frequent cause of serology-negative VA, other conditions must be taken into account in the differential diagnosis of seronegative VA. The rarity of these enteropathies with frequent overlapping of histological features may result in misclassification of such patients as affected by a seronegative or a refractory form of coeliac disease with consequent inappropriate treatments and long-term morbidity. The aim of this review is to summarize the current knowledge and to provide an evidence base and practical algorithmic approach for the investigation and management of seronegative VA.",
keywords = "differential diagnosis, seronegative coeliac disease, villous atrophy",
author = "Annalisa Schiepatti and Sanders, {David S.} and Martina Zuffada and Ombretta Luinetti and Adam Iraqi and Federico Biagi",
year = "2019",
language = "English",
volume = "31",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Overview in the clinical management of patients with seronegative villous atrophy

AU - Schiepatti, Annalisa

AU - Sanders, David S.

AU - Zuffada, Martina

AU - Luinetti, Ombretta

AU - Iraqi, Adam

AU - Biagi, Federico

PY - 2019

Y1 - 2019

N2 - Differential diagnosis and management of enteropathies found in the context of seronegative villous atrophy (VA) are still a clinical challenge. Although seronegative coeliac disease may be the most frequent cause of serology-negative VA, other conditions must be taken into account in the differential diagnosis of seronegative VA. The rarity of these enteropathies with frequent overlapping of histological features may result in misclassification of such patients as affected by a seronegative or a refractory form of coeliac disease with consequent inappropriate treatments and long-term morbidity. The aim of this review is to summarize the current knowledge and to provide an evidence base and practical algorithmic approach for the investigation and management of seronegative VA.

AB - Differential diagnosis and management of enteropathies found in the context of seronegative villous atrophy (VA) are still a clinical challenge. Although seronegative coeliac disease may be the most frequent cause of serology-negative VA, other conditions must be taken into account in the differential diagnosis of seronegative VA. The rarity of these enteropathies with frequent overlapping of histological features may result in misclassification of such patients as affected by a seronegative or a refractory form of coeliac disease with consequent inappropriate treatments and long-term morbidity. The aim of this review is to summarize the current knowledge and to provide an evidence base and practical algorithmic approach for the investigation and management of seronegative VA.

KW - differential diagnosis

KW - seronegative coeliac disease

KW - villous atrophy

M3 - Article

VL - 31

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 4

ER -