Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients

Anna Tessari, Dario Palmieri, Serena Di Cosimo

Research output: Contribution to journalArticlepeer-review

Abstract

Breast cancer includes a body of molecularly distinct subgroups, characterized by different presentation, prognosis, and sensitivity to treatments. Significant advances in our understanding of the complex architecture of this pathology have been achieved in the last few decades, thanks to new biotechnologies that have recently come into the research field and the clinical practice, giving oncologists new instruments that are based on biomarkers and allowing them to set up a personalized approach for each individual patient. Here we review the main treatments available or in preclinical development, the biomolecular diagnostic and prognostic approaches that changed our perspective about breast cancer, giving an overview of targeted therapies that represent the current standard of care for these patients. Finally, we report some examples of how new technologies in clinical practice can set in motion the development of new drugs.

Original languageEnglish
JournalPharmacogenomics and Personalized Medicine
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 16 2013

Keywords

  • Biomarkers
  • Breast cancer
  • Gene expression profile
  • Next generation sequencing
  • Targeted therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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