Overview of epstein–barr-virus-associated gastric cancer correlated with prognostic classification and development of therapeutic options

Valli De Re; Giulia Brisotto; Ombretta Repetto; Mariangela De Zorzi; Laura Caggiari; Stefania Zanussi; Lara Alessandrini; Vincenzo Canzonieri; Gianmaria Miolo; Fabio Puglisi; Claudio Belluco; Agostino Steffan; Renato Cannizzaro

doi:10.3390/ijms21249400

Overview of epstein–barr-virus-associated gastric cancer correlated with prognostic classification and development of therapeutic options

Valli De Re, Giulia Brisotto, Ombretta Repetto, Mariangela De Zorzi, Laura Caggiari, Stefania Zanussi, Lara Alessandrini, Vincenzo Canzonieri, Gianmaria Miolo, Fabio Puglisi, Claudio Belluco, Agostino Steffan, Renato Cannizzaro

Research output: Contribution to journal › Review article › peer-review

Abstract

Gastric cancer (GC) is a deadly disease with poor prognosis that is characterized by heterogeneity. New classifications based on histologic features, genotypes, and molecular phenotypes, for example, the Cancer Genome Atlas subtypes and those by the Asian Cancer Research Group, help understand the carcinogenic differences in GC and have led to the identification of an Epstein–Barr virus (EBV)-related GC subtype (EBVaGC), providing new indications for tailored treatment and prognostic factors. This article provides a review of the features of EBVaGC and an update on the latest insights from EBV-related research with a particular focus on the strict interaction between EBV infection and the gastric tumor environment, including the host immune response. This information may help increase our knowledge of EBVaGC pathogenesis and the mechanisms that sustain the immune response of patients since this mechanism has been demonstrated to offer a survival advantage in a proportion of patients with GC.

Original language	English
Article number	9400
Pages (from-to)	1-23
Number of pages	23
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	24
DOIs	https://doi.org/10.3390/ijms21249400
Publication status	Published - Dec 2 2020

Keywords

Carcinogenesis
Epstein–Barr
Gastric cancer
Targeted drugs

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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De Re, V., Brisotto, G., Repetto, O., De Zorzi, M., Caggiari, L., Zanussi, S., Alessandrini, L., Canzonieri, V., Miolo, G., Puglisi, F., Belluco, C., Steffan, A., & Cannizzaro, R. (2020). Overview of epstein–barr-virus-associated gastric cancer correlated with prognostic classification and development of therapeutic options. International Journal of Molecular Sciences, 21(24), 1-23. [9400]. https://doi.org/10.3390/ijms21249400

Overview of epstein–barr-virus-associated gastric cancer correlated with prognostic classification and development of therapeutic options. / De Re, Valli ; Brisotto, Giulia ; Repetto, Ombretta ; De Zorzi, Mariangela ; Caggiari, Laura ; Zanussi, Stefania; Alessandrini, Lara; Canzonieri, Vincenzo ; Miolo, Gianmaria ; Puglisi, Fabio ; Belluco, Claudio ; Steffan, Agostino ; Cannizzaro, Renato.

In: International Journal of Molecular Sciences, Vol. 21, No. 24, 9400, 02.12.2020, p. 1-23.

Research output: Contribution to journal › Review article › peer-review

De Re, V , Brisotto, G , Repetto, O , De Zorzi, M , Caggiari, L , Zanussi, S, Alessandrini, L, Canzonieri, V , Miolo, G , Puglisi, F , Belluco, C , Steffan, A & Cannizzaro, R 2020, 'Overview of epstein–barr-virus-associated gastric cancer correlated with prognostic classification and development of therapeutic options', International Journal of Molecular Sciences, vol. 21, no. 24, 9400, pp. 1-23. https://doi.org/10.3390/ijms21249400

De Re, Valli ; Brisotto, Giulia ; Repetto, Ombretta ; De Zorzi, Mariangela ; Caggiari, Laura ; Zanussi, Stefania ; Alessandrini, Lara ; Canzonieri, Vincenzo ; Miolo, Gianmaria ; Puglisi, Fabio ; Belluco, Claudio ; Steffan, Agostino ; Cannizzaro, Renato. / Overview of epstein–barr-virus-associated gastric cancer correlated with prognostic classification and development of therapeutic options. In: International Journal of Molecular Sciences. 2020 ; Vol. 21, No. 24. pp. 1-23.

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