Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study)

Pros-IT CNR study group; Alessandro Antonelli; Carlotta Palumbo; Marianna Noale; Walter Artibani; Pierfrancesco Bassi; Filippo Bertoni; Sergio Bracarda; Alessio Bruni; Renzo Corvò; Mauro Gacci; Stefano M. Magrini; Rodolfo Montironi; Angelo Porreca; Andrea Tubaro; Vittorina Zagonel; Stefania Maggi

doi:10.23736/S0393-2249.19.03637-3

Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study)

Pros-IT CNR study group, Alessandro Antonelli, Carlotta Palumbo, Marianna Noale, Walter Artibani, Pierfrancesco Bassi, Filippo Bertoni, Sergio Bracarda, Alessio Bruni, Renzo Corvò, Mauro Gacci, Stefano M. Magrini, Rodolfo Montironi, Angelo Porreca, Andrea Tubaro, Vittorina Zagonel, Stefania Maggi

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: We assessed patients and tumor characteristics, as well as health-related quality of life (HRQoL) items, associated with curative intent treatment decision-making in clinically localized prostate cancer (PCa) patients. METHODS: Clinically localized PCa treated with either radical prostatectomy (RP) or radiation therapy (RT) within 12 months from diagnosis were abstracted from The PROState cancer monitoring in ITaly, from the National Research Council (Pros-IT CNR) database. Multivariable logistic regression (MLR) models predicting RT vs. RP were fitted, after adjustment for HRQoL items, patients and tumor characteristics. RESULTS: Of 1041 patients, 631 (60.2%) were treated with RP and 410 (39.8%) with RT. Relative to RT, RP patients were younger age (mean age 64.5±6.6 vs. 71.4±4.9, P

Original language	English
Pages (from-to)	595-604
Number of pages	10
Journal	Minerva Urologica e Nefrologica
Volume	72
Issue number	5
DOIs	https://doi.org/10.23736/S0393-2249.19.03637-3
Publication status	Published - Oct 1 2020

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group, P-IT. CNR. S., Antonelli, A., Palumbo, C., Noale, M., Artibani, W., Bassi, P., Bertoni, F., Bracarda, S., Bruni, A., Corvò, R., Gacci, M., Magrini, S. M., Montironi, R., Porreca, A., Tubaro, A., Zagonel, V., & Maggi, S. (2020). Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study). Minerva Urologica e Nefrologica, 72(5), 595-604. https://doi.org/10.23736/S0393-2249.19.03637-3

Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study). / group, Pros-IT CNR study; Antonelli, Alessandro; Palumbo, Carlotta; Noale, Marianna; Artibani, Walter; Bassi, Pierfrancesco; Bertoni, Filippo; Bracarda, Sergio; Bruni, Alessio; Corvò, Renzo; Gacci, Mauro; Magrini, Stefano M.; Montironi, Rodolfo; Porreca, Angelo; Tubaro, Andrea; Zagonel, Vittorina; Maggi, Stefania.

In: Minerva Urologica e Nefrologica, Vol. 72, No. 5, 01.10.2020, p. 595-604.

Research output: Contribution to journal › Article › peer-review

group, P-ITCNRS, Antonelli, A, Palumbo, C, Noale, M, Artibani, W, Bassi, P, Bertoni, F, Bracarda, S, Bruni, A, Corvò, R, Gacci, M, Magrini, SM, Montironi, R, Porreca, A, Tubaro, A, Zagonel, V & Maggi, S 2020, 'Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study)', Minerva Urologica e Nefrologica, vol. 72, no. 5, pp. 595-604. https://doi.org/10.23736/S0393-2249.19.03637-3

group P-ITCNRS, Antonelli A, Palumbo C, Noale M, Artibani W, Bassi P et al. Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study). Minerva Urologica e Nefrologica. 2020 Oct 1;72(5):595-604. https://doi.org/10.23736/S0393-2249.19.03637-3

group, Pros-IT CNR study ; Antonelli, Alessandro ; Palumbo, Carlotta ; Noale, Marianna ; Artibani, Walter ; Bassi, Pierfrancesco ; Bertoni, Filippo ; Bracarda, Sergio ; Bruni, Alessio ; Corvò, Renzo ; Gacci, Mauro ; Magrini, Stefano M. ; Montironi, Rodolfo ; Porreca, Angelo ; Tubaro, Andrea ; Zagonel, Vittorina ; Maggi, Stefania. / Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study). In: Minerva Urologica e Nefrologica. 2020 ; Vol. 72, No. 5. pp. 595-604.

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abstract = "BACKGROUND: We assessed patients and tumor characteristics, as well as health-related quality of life (HRQoL) items, associated with curative intent treatment decision-making in clinically localized prostate cancer (PCa) patients. METHODS: Clinically localized PCa treated with either radical prostatectomy (RP) or radiation therapy (RT) within 12 months from diagnosis were abstracted from The PROState cancer monitoring in ITaly, from the National Research Council (Pros-IT CNR) database. Multivariable logistic regression (MLR) models predicting RT vs. RP were fitted, after adjustment for HRQoL items, patients and tumor characteristics. RESULTS: Of 1041 patients, 631 (60.2%) were treated with RP and 410 (39.8%) with RT. Relative to RT, RP patients were younger age (mean age 64.5±6.6 vs. 71.4±4.9, P",

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AU - Palumbo, Carlotta

AU - Noale, Marianna

AU - Artibani, Walter

AU - Bassi, Pierfrancesco

AU - Bertoni, Filippo

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AU - Bruni, Alessio

AU - Corvò, Renzo

AU - Gacci, Mauro

AU - Magrini, Stefano M.

AU - Montironi, Rodolfo

AU - Porreca, Angelo

AU - Tubaro, Andrea

AU - Zagonel, Vittorina

AU - Maggi, Stefania

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2020/10/1

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N2 - BACKGROUND: We assessed patients and tumor characteristics, as well as health-related quality of life (HRQoL) items, associated with curative intent treatment decision-making in clinically localized prostate cancer (PCa) patients. METHODS: Clinically localized PCa treated with either radical prostatectomy (RP) or radiation therapy (RT) within 12 months from diagnosis were abstracted from The PROState cancer monitoring in ITaly, from the National Research Council (Pros-IT CNR) database. Multivariable logistic regression (MLR) models predicting RT vs. RP were fitted, after adjustment for HRQoL items, patients and tumor characteristics. RESULTS: Of 1041 patients, 631 (60.2%) were treated with RP and 410 (39.8%) with RT. Relative to RT, RP patients were younger age (mean age 64.5±6.6 vs. 71.4±4.9, P

AB - BACKGROUND: We assessed patients and tumor characteristics, as well as health-related quality of life (HRQoL) items, associated with curative intent treatment decision-making in clinically localized prostate cancer (PCa) patients. METHODS: Clinically localized PCa treated with either radical prostatectomy (RP) or radiation therapy (RT) within 12 months from diagnosis were abstracted from The PROState cancer monitoring in ITaly, from the National Research Council (Pros-IT CNR) database. Multivariable logistic regression (MLR) models predicting RT vs. RP were fitted, after adjustment for HRQoL items, patients and tumor characteristics. RESULTS: Of 1041 patients, 631 (60.2%) were treated with RP and 410 (39.8%) with RT. Relative to RT, RP patients were younger age (mean age 64.5±6.6 vs. 71.4±4.9, P

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