Overview of radiomics in breast cancer diagnosis and prognostication

Alberto Stefano Tagliafico, Michele Piana, Daniela Schenone, Rita Lai, Anna Maria Massone, Nehmat Houssami

Research output: Contribution to journalArticle

Abstract

Diagnosis of early invasive breast cancer relies on radiology and clinical evaluation, supplemented by biopsy confirmation. At least three issues burden this approach: a) suboptimal sensitivity and suboptimal positive predictive power of radiology screening and diagnostic approaches, respectively; b) invasiveness of biopsy with discomfort for women undergoing diagnostic tests; c) long turnaround time for recall tests. In the screening setting, radiology sensitivity is suboptimal, and when a suspicious lesion is detected and a biopsy is recommended, the positive predictive value of radiology is modest. Recent technological advances in medical imaging, especially in the field of artificial intelligence applied to image analysis, hold promise in addressing clinical challenges in cancer detection, assessment of treatment response, and monitoring disease progression. Radiomics include feature extraction from clinical images; these features are related to tumor size, shape, intensity, and texture, collectively providing comprehensive tumor characterization, the so-called radiomics signature of the tumor. Radiomics is based on the hypothesis that extracted quantitative data derives from mechanisms occurring at genetic and molecular levels. In this article we focus on the role and potential of radiomics in breast cancer diagnosis and prognostication.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalBreast
Volume49
DOIs
Publication statusPublished - Feb 2020

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Radiology
Breast Neoplasms
Biopsy
Neoplasms
Artificial Intelligence
Diagnostic Imaging
Routine Diagnostic Tests
Disease Progression
Molecular Biology
Therapeutics

Keywords

  • Artificial intelligence
  • Breast cancer
  • Digital breast tomosynthesis
  • Magnetic resonance imaging
  • Prediction
  • Radiomics

ASJC Scopus subject areas

  • Surgery

Cite this

Tagliafico, A. S., Piana, M., Schenone, D., Lai, R., Massone, A. M., & Houssami, N. (2020). Overview of radiomics in breast cancer diagnosis and prognostication. Breast, 49, 74-80. https://doi.org/10.1016/j.breast.2019.10.018

Overview of radiomics in breast cancer diagnosis and prognostication. / Tagliafico, Alberto Stefano; Piana, Michele; Schenone, Daniela; Lai, Rita; Massone, Anna Maria; Houssami, Nehmat.

In: Breast, Vol. 49, 02.2020, p. 74-80.

Research output: Contribution to journalArticle

Tagliafico, AS, Piana, M, Schenone, D, Lai, R, Massone, AM & Houssami, N 2020, 'Overview of radiomics in breast cancer diagnosis and prognostication', Breast, vol. 49, pp. 74-80. https://doi.org/10.1016/j.breast.2019.10.018
Tagliafico, Alberto Stefano ; Piana, Michele ; Schenone, Daniela ; Lai, Rita ; Massone, Anna Maria ; Houssami, Nehmat. / Overview of radiomics in breast cancer diagnosis and prognostication. In: Breast. 2020 ; Vol. 49. pp. 74-80.
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