Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

Giuseppe Tardiolo, Placido Bramanti, Emanuela Mazzon

Research output: Contribution to journalReview articlepeer-review


N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially available and no relevant side effects were observed after its administration. The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson's and Alzheimer's disorders and in neuropathic pain and stroke.

Original languageEnglish
Issue number12
Publication statusPublished - Dec 13 2018


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