Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection

Massimiliano Berretta, Arben Lleshi, Alessandro Cappellani, Alessandra Bearz, Michele Spina, Renato Talamini, Bruno Cacopardo, Giuseppe Nunnari, Vincenzo Montesarchio, Immacolata Izzi, Massimiliano Lanzafame, Guglielmo Nasti, Francesco Basile, Salvatore Berretta, Rossella Fisichella, Clara C. Schiantarelli, Elisa Garlassi, Annalisa Ridolfo, Lorenza Guella, Umberto Tirelli

Research output: Contribution to journalArticle

Abstract

Background: Although FOLFOX4 is considered the standard chemotherapy regimen for colorectal cancer (CRC), few data are available on its results in human immunodeficiency (HIV)-related CRC. The results were analyzed to evaluate feasibility and activity of FOLFOX4 plus highly active antiretroviral therapy (HAART) in metastatic CRC (mCRC) HIV-seropositive patients. Patients and Methods: From January 2002 to March 2007, 24 patients were selected among the CRC HIV-seropositive patients treated with FOLFOX4 and concomitant HAART within the Italian Cooperative Group on AIDS and Tumors (GICAT). Results: Four median cycles of chemotherapy were administered; the most common severe toxicity was neutropenia (37.5%). An overall response rate of 50% was observed; 4.2% of patients achieved complete response and 45.8% partial response. No opportunistic infections occurred during or immediately after chemotherapy. The median CD4+ count was 380 (range 220-570) at diagnosis. Conclusions: To our knowledge, this is the largest study describing activity and tolerability of FOLFOX4 and HAART, in this setting. FOLFOX4 plus concomitant HAART resulted feasible and active also in HIV-seropositive patients. Moreover, the concomitant use of HAART did not seem to increase the FOLFOX4 toxicity. This study suggests the good tolerability of the FOLFOX4, making it a reasonable option for combination with HAART.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalCurrent HIV Research
Volume8
Issue number3
DOIs
Publication statusPublished - Apr 2010

    Fingerprint

Keywords

  • Chemotherapy
  • FOLFOX4
  • HAART
  • HIV-infection
  • Metastatic colorectal cancer
  • Treatment

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Berretta, M., Lleshi, A., Cappellani, A., Bearz, A., Spina, M., Talamini, R., Cacopardo, B., Nunnari, G., Montesarchio, V., Izzi, I., Lanzafame, M., Nasti, G., Basile, F., Berretta, S., Fisichella, R., Schiantarelli, C. C., Garlassi, E., Ridolfo, A., Guella, L., & Tirelli, U. (2010). Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection. Current HIV Research, 8(3), 218-222. https://doi.org/10.2174/157016210791111061