Oxatomide in the treatment of atopic dermatitis in breast-fed and very young infants

A. Boccazzi, L. Pugni, R. Cesuti, S. Rapuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background. This study was designed to assess the efficacy and safety of oxatomide oral suspension, in breast-fed and young babies with atopic dermatitis. Methods. Thirty-one children (11 females, 20 males) aged between 4 and 35 months (mean ± SD 15.4 ± 7.6 months) were treated with oxatomide (2.5 mg/mL) at a dose of 1 mg/kg/day) split into two doses, every 12 hrs; treatment lasted 30 days. Efficacy was evaluated on the basis of the following signs and symptoms: itching (severity, extension and duration), blisters (number, extension), erythema (severity, extension), papules (number, extension), lesions from scratching (yes/no), dry skin (yes/no). Results. Skin signs improved significantly with oxatomide. Itching was reduced 58.2% from baseline, and erythema 57.6% (both p <0.001). Vesicles, papules, lesions due to scratching and dry skin also improved significantly. Oxatomide had to be stopped only in one child in whom the dermatitis became worse. Conclusions. These results show the efficacy and safety of oxatomide in breast-fed or very young babies with atopic dermatitis. The oral suspension was particularly easy to use in children less than two years old, on account of the simple dosage schedule.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalMinerva Pediatrica
Volume53
Issue number4
Publication statusPublished - Aug 2001

Keywords

  • Breast-feeding
  • Dermatitis, atopic
  • Piperazines, therapeutic use

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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