TY - JOUR
T1 - Oxcarbazepine-induced myoclonic status epilepticus in juvenile myoclonic epilepsy
AU - Fanella, Martina
AU - Egeo, Gabriella
AU - Fattouch, Jinane
AU - Casciato, Sara
AU - Lapenta, Leonardo
AU - Morano, Alessandra
AU - Giallonardo, Anna Teresa
AU - Di Bonaventura, Carlo
PY - 2013/6
Y1 - 2013/6
N2 - Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be under-diagnosed or misdiagnosed; in the latter case, it may be mistaken for partial epilepsy. The incorrect diagnosis of JME is likely to result in inappropriate therapy, which may, in turn, worsen the seizures. While a number of studies have documented that carbamazepine aggravates idiopathic generalised epilepsy, few have shown a worsening of symptoms following the administration of oxcarbazepine (OXC). We report the case of a 44-year-old male affected by JME in which the inappropriate use of OXC precipitated a dramatic worsening of myoclonic seizures. In this case, video-EEG monitoring documented myoclonic status epilepticus with positive and negative myoclonus, correlating with repetitive, continuous, rhythmic, generalised polyspike-and-wave discharges. This is the first case of myoclonic status epilepticus induced by OXC in a patient with JME which is clearly documented by video-EEG. A review of the literature with regards to OXC-induced worsening of seizures is also presented.
AB - Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be under-diagnosed or misdiagnosed; in the latter case, it may be mistaken for partial epilepsy. The incorrect diagnosis of JME is likely to result in inappropriate therapy, which may, in turn, worsen the seizures. While a number of studies have documented that carbamazepine aggravates idiopathic generalised epilepsy, few have shown a worsening of symptoms following the administration of oxcarbazepine (OXC). We report the case of a 44-year-old male affected by JME in which the inappropriate use of OXC precipitated a dramatic worsening of myoclonic seizures. In this case, video-EEG monitoring documented myoclonic status epilepticus with positive and negative myoclonus, correlating with repetitive, continuous, rhythmic, generalised polyspike-and-wave discharges. This is the first case of myoclonic status epilepticus induced by OXC in a patient with JME which is clearly documented by video-EEG. A review of the literature with regards to OXC-induced worsening of seizures is also presented.
KW - JME
KW - Juvenile myoclonic epilepsy
KW - Myoclonic status epilepticus
KW - OXC
KW - Seizure
KW - Worsen
UR - http://www.scopus.com/inward/record.url?scp=84880451296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880451296&partnerID=8YFLogxK
U2 - 10.1684/epd.2013.0563
DO - 10.1684/epd.2013.0563
M3 - Article
C2 - 23774821
AN - SCOPUS:84880451296
VL - 15
SP - 181
EP - 187
JO - Epileptic Disorders
JF - Epileptic Disorders
SN - 1294-9361
IS - 2
ER -