Oxcarbazepine-induced myoclonic status epilepticus in juvenile myoclonic epilepsy

Martina Fanella, Gabriella Egeo, Jinane Fattouch, Sara Casciato, Leonardo Lapenta, Alessandra Morano, Anna Teresa Giallonardo, Carlo Di Bonaventura

Research output: Contribution to journalArticlepeer-review

Abstract

Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be under-diagnosed or misdiagnosed; in the latter case, it may be mistaken for partial epilepsy. The incorrect diagnosis of JME is likely to result in inappropriate therapy, which may, in turn, worsen the seizures. While a number of studies have documented that carbamazepine aggravates idiopathic generalised epilepsy, few have shown a worsening of symptoms following the administration of oxcarbazepine (OXC). We report the case of a 44-year-old male affected by JME in which the inappropriate use of OXC precipitated a dramatic worsening of myoclonic seizures. In this case, video-EEG monitoring documented myoclonic status epilepticus with positive and negative myoclonus, correlating with repetitive, continuous, rhythmic, generalised polyspike-and-wave discharges. This is the first case of myoclonic status epilepticus induced by OXC in a patient with JME which is clearly documented by video-EEG. A review of the literature with regards to OXC-induced worsening of seizures is also presented.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalEpileptic Disorders
Volume15
Issue number2
DOIs
Publication statusPublished - Jun 2013

Keywords

  • JME
  • Juvenile myoclonic epilepsy
  • Myoclonic status epilepticus
  • OXC
  • Seizure
  • Worsen

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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